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Article

The Potential of Liquid Biopsy in Detection of Endometrial Cancer Biomarkers: A Pilot Study

by
Dominik Kodada
1,2,*,
Michaela Hyblova
1,
Patrik Krumpolec
1,
Nikola Janostiakova
1,2,
Peter Barath
1,
Marian Grendar
1,3,
Gabriela Blandova
2,
Oliver Petrovic
1,
Pavol Janega
1,2,
Vanda Repiska
2 and
Gabriel Minarik
1
1
Medirex Group Academy, 94905 Nitra, Slovakia
2
Faculty of Medicine, Comenius University in Bratislava, 84215 Bratislava, Slovakia
3
Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(9), 7811; https://doi.org/10.3390/ijms24097811
Submission received: 3 April 2023 / Revised: 19 April 2023 / Accepted: 20 April 2023 / Published: 25 April 2023
(This article belongs to the Special Issue Liquid Biopsy in Cancers)
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Abstract

Endometrial cancer belongs to the most common gynecologic cancer types globally, with increasing incidence. There are numerous ways of classifying different cases. The most recent decade has brought advances in molecular classification, which show more accurate prognostic factors and the possibility of personalised adjuvant treatment. In addition, diagnostic approaches lag behind these advances, with methods causing patients discomfort while lacking the reproducibility of tissue sampling for biopsy. Minimally invasive liquid biopsies could therefore represent an alternative screening and diagnostic approach in patients with endometrial cancer. The method could potentially detect molecular changes in this cancer type and identify patients at early stages. In this pilot study, we tested such a detection method based on circulating tumour DNA isolated from the peripheral blood plasma of 21 Slovak endometrial cancer patients. We successfully detected oncomutations in the circulating DNA of every single patient, although the prognostic value of the detected mutations failed to offer certainty. Furthermore, we detected changes associated with clonal hematopoiesis, including DNMT3A mutations, which were present in the majority of circulating tumour DNA samples.
Keywords: endometrial cancer; liquid biopsy; ctDNA; DNMT3A mutations endometrial cancer; liquid biopsy; ctDNA; DNMT3A mutations

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MDPI and ACS Style

Kodada, D.; Hyblova, M.; Krumpolec, P.; Janostiakova, N.; Barath, P.; Grendar, M.; Blandova, G.; Petrovic, O.; Janega, P.; Repiska, V.; et al. The Potential of Liquid Biopsy in Detection of Endometrial Cancer Biomarkers: A Pilot Study. Int. J. Mol. Sci. 2023, 24, 7811. https://doi.org/10.3390/ijms24097811

AMA Style

Kodada D, Hyblova M, Krumpolec P, Janostiakova N, Barath P, Grendar M, Blandova G, Petrovic O, Janega P, Repiska V, et al. The Potential of Liquid Biopsy in Detection of Endometrial Cancer Biomarkers: A Pilot Study. International Journal of Molecular Sciences. 2023; 24(9):7811. https://doi.org/10.3390/ijms24097811

Chicago/Turabian Style

Kodada, Dominik, Michaela Hyblova, Patrik Krumpolec, Nikola Janostiakova, Peter Barath, Marian Grendar, Gabriela Blandova, Oliver Petrovic, Pavol Janega, Vanda Repiska, and et al. 2023. "The Potential of Liquid Biopsy in Detection of Endometrial Cancer Biomarkers: A Pilot Study" International Journal of Molecular Sciences 24, no. 9: 7811. https://doi.org/10.3390/ijms24097811

APA Style

Kodada, D., Hyblova, M., Krumpolec, P., Janostiakova, N., Barath, P., Grendar, M., Blandova, G., Petrovic, O., Janega, P., Repiska, V., & Minarik, G. (2023). The Potential of Liquid Biopsy in Detection of Endometrial Cancer Biomarkers: A Pilot Study. International Journal of Molecular Sciences, 24(9), 7811. https://doi.org/10.3390/ijms24097811

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