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Article

Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules

by
Filitsa Dimiza
1,
Amalia Barmpa
1,
Antonios Chronakis
2,
Antonios G. Hatzidimitriou
1,
Yiannis Sanakis
3,
Athanasios N. Papadopoulos
2 and
George Psomas
1,*
1
Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
2
Department of Nutritional Sciences and Dietetics, International Hellenic University, GR-57400 Thessaloniki, Greece
3
Institute of Nanoscience and Nanotechnology, National Centre of Scientific Research “Demokritos”, GR-15310 Agia Paraskevi, Greece
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(7), 6391; https://doi.org/10.3390/ijms24076391
Submission received: 7 March 2023 / Revised: 22 March 2023 / Accepted: 24 March 2023 / Published: 28 March 2023
(This article belongs to the Special Issue Metal Ions in Health and Disease)
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Abstract

One the main research goals of bioinorganic chemists is the synthesis of novel coordination compounds possessing biological potency. Within this context, three novel iron(III) complexes with the non-steroidal anti-inflammatory drugs diflunisal and diclofenac in the presence or absence of the nitrogen donors 1,10-phenanthroline or pyridine were isolated and characterized by diverse techniques. The complexes were evaluated for their ability to scavenge in vitro free radicals such as hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, revealing their selective potency towards hydroxyl radicals. The in vitro inhibitory activity of the complexes towards the enzymes acetylcholinesterase and butyrylcholinesterase was evaluated, and their potential to achieve neuroprotection appeared promising. The interaction of the complexes with calf-thymus DNA was examined in vitro, revealing their ability to intercalate in-between DNA nucleobases. The affinity of the complexes for serum albumins was evaluated in vitro and revealed their tight and reversible binding.
Keywords: iron(III) complexes; non-steroidal anti-inflammatory drugs; antioxidant activity; anticholinergic activity; interaction with albumins; interaction with DNA iron(III) complexes; non-steroidal anti-inflammatory drugs; antioxidant activity; anticholinergic activity; interaction with albumins; interaction with DNA

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MDPI and ACS Style

Dimiza, F.; Barmpa, A.; Chronakis, A.; Hatzidimitriou, A.G.; Sanakis, Y.; Papadopoulos, A.N.; Psomas, G. Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules. Int. J. Mol. Sci. 2023, 24, 6391. https://doi.org/10.3390/ijms24076391

AMA Style

Dimiza F, Barmpa A, Chronakis A, Hatzidimitriou AG, Sanakis Y, Papadopoulos AN, Psomas G. Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules. International Journal of Molecular Sciences. 2023; 24(7):6391. https://doi.org/10.3390/ijms24076391

Chicago/Turabian Style

Dimiza, Filitsa, Amalia Barmpa, Antonios Chronakis, Antonios G. Hatzidimitriou, Yiannis Sanakis, Athanasios N. Papadopoulos, and George Psomas. 2023. "Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules" International Journal of Molecular Sciences 24, no. 7: 6391. https://doi.org/10.3390/ijms24076391

APA Style

Dimiza, F., Barmpa, A., Chronakis, A., Hatzidimitriou, A. G., Sanakis, Y., Papadopoulos, A. N., & Psomas, G. (2023). Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules. International Journal of Molecular Sciences, 24(7), 6391. https://doi.org/10.3390/ijms24076391

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