The Role of Adipokines in the Pathogenesis of Psoriasis
Abstract
:1. Introduction
1.1. Pathogenesis of Psoriasis
1.2. Problems in the Diagnosis and Management of Psoriasis
1.3. Adipokines
2. Adiponectin
2.1. Structure, Signaling Pathways, and Physiological Role of Adiponectin
2.2. Impact of Adiponectin on Skin and Joints
2.3. The Role of Adiponectin in Psoriasis
3. Leptin
3.1. Leptin in Physiology and Pathology
3.2. The Role of Leptin in Psoriasis
4. Other Adipokines and Their Role in Psoriasis
4.1. Visfatin
4.2. Resistin
4.3. Chemerin
4.4. Irisin
4.5. C1q/tumor Necrosis Factor-Related Protein 3
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Adipokine | Expression in Psoriasis | Psoriasis-Related Immunomodulatory Effects | Reference |
---|---|---|---|
Adiponectin | Decreased | Negative correlation between adiponectin and IL-23 gene expression in patients with high LDL Adiponectin deficiency promotes IL-23p19 and IL-17 Adiponectin suppresses IL-17 production in IL-23-stimulated dermal γδ-T cells Intraperitoneal injection of adiponectin resulted in inhibition of IL-17 production in adiponectin-deficient mice | [122,123,126,127] |
Leptin | Elevated | Leptin Promotes Th17 differentiation Leptin neutralization promotes Treg proliferation | [26,153,155,160] |
Visfatin | Elevated | Visfatin enhances inflammatory responses in keratinocytes induced by TNF-α | [170,171,172] |
Resistin | Elevated | Resistin may suppress IL-23p19 in dendritic cells | [122,188,192] |
Chemerin | Elevated | Chemerin might promote migration of dendritic cells, which actively take part in psoriasis pathogenesis Chemerin promotes secretion of pro-inflammatory cytokines in keratinocytes | [209,210,212,213] |
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Kiełbowski, K.; Bakinowska, E.; Ostrowski, P.; Pala, B.; Gromowska, E.; Gurazda, K.; Dec, P.; Modrzejewski, A.; Pawlik, A. The Role of Adipokines in the Pathogenesis of Psoriasis. Int. J. Mol. Sci. 2023, 24, 6390. https://doi.org/10.3390/ijms24076390
Kiełbowski K, Bakinowska E, Ostrowski P, Pala B, Gromowska E, Gurazda K, Dec P, Modrzejewski A, Pawlik A. The Role of Adipokines in the Pathogenesis of Psoriasis. International Journal of Molecular Sciences. 2023; 24(7):6390. https://doi.org/10.3390/ijms24076390
Chicago/Turabian StyleKiełbowski, Kajetan, Estera Bakinowska, Piotr Ostrowski, Bartłomiej Pala, Ewa Gromowska, Klaudia Gurazda, Paweł Dec, Andrzej Modrzejewski, and Andrzej Pawlik. 2023. "The Role of Adipokines in the Pathogenesis of Psoriasis" International Journal of Molecular Sciences 24, no. 7: 6390. https://doi.org/10.3390/ijms24076390