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Article

Metadherin Regulates Inflammatory Breast Cancer Invasion and Metastasis

by
Gabriela Ortiz-Soto
1,
Natalia S. Babilonia-Díaz
1,
Mercedes Y. Lacourt-Ventura
1,
Delmarie M. Rivera-Rodríguez
1,
Jailenne I. Quiñones-Rodríguez
2,3,
Mónica Colón-Vargas
4,
Israel Almodóvar-Rivera
4,
Luis E. Ferrer-Torres
5,6,
Ivette J. Suárez-Arroyo
1 and
Michelle M. Martínez-Montemayor
1,*
1
Department of Biochemistry, Universidad Central del Caribe-School of Medicine, Bayamón, PR 00960, USA
2
Department of Clinical Anatomy, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, USA
3
Department of Anatomy and Cell Biology, School of Medicine, Universidad Central del Caribe, Bayamón, PR 00960, USA
4
Department of Mathematical Sciences, University of Puerto Rico at Mayagüez, Mayagüez, PR 00681, USA
5
Department of Pathology and Laboratory Medicine, Hospital Interamericano de Medicina Avanzada (H.I.M.A.)—San Pablo Caguas, Caguas, PR 00725, USA
6
Department of Immunopathology, Hato Rey Pathology Associates Inc. (HRPLABS), San Juan, PR 00936, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(5), 4694; https://doi.org/10.3390/ijms24054694
Submission received: 5 January 2023 / Revised: 25 February 2023 / Accepted: 26 February 2023 / Published: 28 February 2023
(This article belongs to the Section Molecular Immunology)
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Abstract

Inflammatory breast cancer (IBC) is one of the most lethal subtypes of breast cancer (BC), accounting for approximately 1–5% of all cases of BC. Challenges in IBC include accurate and early diagnosis and the development of effective targeted therapies. Our previous studies identified the overexpression of metadherin (MTDH) in the plasma membrane of IBC cells, further confirmed in patient tissues. MTDH has been found to play a role in signaling pathways related to cancer. However, its mechanism of action in the progression of IBC remains unknown. To evaluate the function of MTDH, SUM-149 and SUM-190 IBC cells were edited with CRISPR/Cas9 vectors for in vitro characterization studies and used in mouse IBC xenografts. Our results demonstrate that the absence of MTDH significantly reduces IBC cell migration, proliferation, tumor spheroid formation, and the expression of NF-κB and STAT3 signaling molecules, which are crucial oncogenic pathways in IBC. Furthermore, IBC xenografts showed significant differences in tumor growth patterns, and lung tissue revealed epithelial-like cells in 43% of wild-type (WT) compared to 29% of CRISPR xenografts. Our study emphasizes the role of MTDH as a potential therapeutic target for the progression of IBC.
Keywords: metadherin; inflammatory breast cancer; invasion; metastasis metadherin; inflammatory breast cancer; invasion; metastasis

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MDPI and ACS Style

Ortiz-Soto, G.; Babilonia-Díaz, N.S.; Lacourt-Ventura, M.Y.; Rivera-Rodríguez, D.M.; Quiñones-Rodríguez, J.I.; Colón-Vargas, M.; Almodóvar-Rivera, I.; Ferrer-Torres, L.E.; Suárez-Arroyo, I.J.; Martínez-Montemayor, M.M. Metadherin Regulates Inflammatory Breast Cancer Invasion and Metastasis. Int. J. Mol. Sci. 2023, 24, 4694. https://doi.org/10.3390/ijms24054694

AMA Style

Ortiz-Soto G, Babilonia-Díaz NS, Lacourt-Ventura MY, Rivera-Rodríguez DM, Quiñones-Rodríguez JI, Colón-Vargas M, Almodóvar-Rivera I, Ferrer-Torres LE, Suárez-Arroyo IJ, Martínez-Montemayor MM. Metadherin Regulates Inflammatory Breast Cancer Invasion and Metastasis. International Journal of Molecular Sciences. 2023; 24(5):4694. https://doi.org/10.3390/ijms24054694

Chicago/Turabian Style

Ortiz-Soto, Gabriela, Natalia S. Babilonia-Díaz, Mercedes Y. Lacourt-Ventura, Delmarie M. Rivera-Rodríguez, Jailenne I. Quiñones-Rodríguez, Mónica Colón-Vargas, Israel Almodóvar-Rivera, Luis E. Ferrer-Torres, Ivette J. Suárez-Arroyo, and Michelle M. Martínez-Montemayor. 2023. "Metadherin Regulates Inflammatory Breast Cancer Invasion and Metastasis" International Journal of Molecular Sciences 24, no. 5: 4694. https://doi.org/10.3390/ijms24054694

APA Style

Ortiz-Soto, G., Babilonia-Díaz, N. S., Lacourt-Ventura, M. Y., Rivera-Rodríguez, D. M., Quiñones-Rodríguez, J. I., Colón-Vargas, M., Almodóvar-Rivera, I., Ferrer-Torres, L. E., Suárez-Arroyo, I. J., & Martínez-Montemayor, M. M. (2023). Metadherin Regulates Inflammatory Breast Cancer Invasion and Metastasis. International Journal of Molecular Sciences, 24(5), 4694. https://doi.org/10.3390/ijms24054694

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