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Review

Vitamin D and Diabetic Kidney Disease

by
Ho-Yin Huang
1,2,
Ting-Wei Lin
3,
Zi-Xuan Hong
3 and
Lee-Moay Lim
3,4,5,*
1
Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5
School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(4), 3751; https://doi.org/10.3390/ijms24043751
Submission received: 27 November 2022 / Revised: 28 January 2023 / Accepted: 9 February 2023 / Published: 13 February 2023
(This article belongs to the Special Issue Novel Aspects in Kidney Disease in Diabetes 2.0)
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Abstract

Vitamin D is a hormone involved in many physiological processes. Its active form, 1,25(OH)2D3, modulates serum calcium–phosphate homeostasis and skeletal homeostasis. A growing body of evidence has demonstrated the renoprotective effects of vitamin D. Vitamin D modulates endothelial function, is associated with podocyte preservation, regulates the renin–angiotensin–aldosterone system, and has anti-inflammatory effects. Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease worldwide. There are numerous studies supporting vitamin D as a renoprotector, potentially delaying the onset of DKD. This review summarizes the findings of current research on vitamin D and its role in DKD.
Keywords: Vitamin D; 1,25(OH)2D3; vitamin D receptor (VDR); diabetic kidney disease (DKD); diabetic nephropathy (DN) Vitamin D; 1,25(OH)2D3; vitamin D receptor (VDR); diabetic kidney disease (DKD); diabetic nephropathy (DN)

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MDPI and ACS Style

Huang, H.-Y.; Lin, T.-W.; Hong, Z.-X.; Lim, L.-M. Vitamin D and Diabetic Kidney Disease. Int. J. Mol. Sci. 2023, 24, 3751. https://doi.org/10.3390/ijms24043751

AMA Style

Huang H-Y, Lin T-W, Hong Z-X, Lim L-M. Vitamin D and Diabetic Kidney Disease. International Journal of Molecular Sciences. 2023; 24(4):3751. https://doi.org/10.3390/ijms24043751

Chicago/Turabian Style

Huang, Ho-Yin, Ting-Wei Lin, Zi-Xuan Hong, and Lee-Moay Lim. 2023. "Vitamin D and Diabetic Kidney Disease" International Journal of Molecular Sciences 24, no. 4: 3751. https://doi.org/10.3390/ijms24043751

APA Style

Huang, H.-Y., Lin, T.-W., Hong, Z.-X., & Lim, L.-M. (2023). Vitamin D and Diabetic Kidney Disease. International Journal of Molecular Sciences, 24(4), 3751. https://doi.org/10.3390/ijms24043751

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