A Thermodynamic Approach to the Metaboloepigenetics of Cancer
Abstract
:1. Introduction
- Mechanical energy, related to cellular movement, reorganization of intracellular structures, and changes of cell shape;
- Electrical energy, related to electron flow due to differences in voltage;
- Electromagnetic energy, related to thermal radiation, etc.;
- Chemical energy, related to biochemical reactions, but also to growth as an increase of molecules and biological structures;
- Heat transfer, as outflow due to wasted energy released into the cell microenvironment;
- Quantum energy, related to the structure of molecules and their quantum-level interactions.
2. Results
- Any change in the cell membrane’s electric potential generates entropy (); as such, this process is irreversible unless the cell consumes metabolites (to reverse the potential if needed). This proves the strict correlation between energy management and cell activity;
- The change of the membrane’s electric potential can be controlled by the inflow and outflow of ions (), which highlights the close interaction between environment and cell activity, as asserted by epigenetics;
- Any change in the cell membrane potential is related to energy management and ion concentration, as represented by the Nernst equation.
- We consider the ideal case ( W m K): it allows us to evaluate the maximum value of the ion fluxes;
- We consider the stationary state ().
3. Discussion
4. Materials and Methods
- For normal cells: the Krebs cycle, which consists of chemical reactions to convert stored energy through the oxidation of acetyl-CoA, using carbohydrates, lipids, and proteins;
- The Second Law of Thermodynamics results in [59,60]
- The volume of the cell (), which is related to cell proliferation;
- The fluxes of ions (), which are related to the metabolic requirements, respiration, communication, molecule formation and epigenetic effects;
- The heat discharged towards the environment (), due to irreversibility.
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
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Lucia, U.; Deisboeck, T.S.; Ponzetto, A.; Grisolia, G. A Thermodynamic Approach to the Metaboloepigenetics of Cancer. Int. J. Mol. Sci. 2023, 24, 3337. https://doi.org/10.3390/ijms24043337
Lucia U, Deisboeck TS, Ponzetto A, Grisolia G. A Thermodynamic Approach to the Metaboloepigenetics of Cancer. International Journal of Molecular Sciences. 2023; 24(4):3337. https://doi.org/10.3390/ijms24043337
Chicago/Turabian StyleLucia, Umberto, Thomas S. Deisboeck, Antonio Ponzetto, and Giulia Grisolia. 2023. "A Thermodynamic Approach to the Metaboloepigenetics of Cancer" International Journal of Molecular Sciences 24, no. 4: 3337. https://doi.org/10.3390/ijms24043337