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Article

MicroRNA Expression in Subretinal Fluid in Eyes Affected by Rhegmatogenous Retinal Detachment

by
Paolo Carpineto
1,2,*,†,
Ester Sara Di Filippo
3,†,
Agbeanda Aharrh Gnama
2,
Danilo Bondi
3,
Carla Iafigliola
2,
Arturo Maria Licata
1,2 and
Stefania Fulle
3
1
Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
2
Ophthalmology Clinic, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
3
Department of Neuroscience, Imaging and Clinical Sciences, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2023, 24(3), 3032; https://doi.org/10.3390/ijms24033032
Submission received: 30 December 2022 / Revised: 29 January 2023 / Accepted: 2 February 2023 / Published: 3 February 2023
(This article belongs to the Special Issue Advanced Research in Retina)
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Abstract

Proliferative vitreoretinopathy (PVR) is an abnormal intraocular scarring process that can complicate cases of rhegmatogenous retinal detachment (RRD). Although previous studies have examined the relevance of microRNAs (miRNAs) in ophthalmic diseases, only a few studies have evaluated the expression profiles of microRNAs in subretinal fluid. We hypothesized that the expression profiles of specific miRNAs may change in response to RRD, in the subretinal fluid that is directly in contact with photoreceptors and the retinal pigment epithelium (RPE). We looked for a potential correlation between the expression of specific miRNAs in eyes with RRD and known clinical risk factors of PVR. A total of 24 patients (59 ± 11 years) who underwent scleral buckling procedure were enrolled in this prospective study. Twenty-four undiluted subretinal fluid samples were collected, RNA was isolated and qRT-PCR was performed to analyze the expression of 12 miRNAs. We found the existence of a positive association between the expression of miR-21 (p = 0.017, r = 0.515) and miR-34 (p = 0.030, r = 0.624) and the duration of symptoms related to retinal detachment. Moreover, the expression of miR-146a tended to decrease in patients who developed PVR. Subretinal fluid constitutes an intriguing biological matrix to evaluate the role of miRNAs leading to the development of PVR.
Keywords: RRD; SRF; miRNAs; proliferative vitreoretinopathy; PVR; myopia RRD; SRF; miRNAs; proliferative vitreoretinopathy; PVR; myopia

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MDPI and ACS Style

Carpineto, P.; Di Filippo, E.S.; Aharrh Gnama, A.; Bondi, D.; Iafigliola, C.; Licata, A.M.; Fulle, S. MicroRNA Expression in Subretinal Fluid in Eyes Affected by Rhegmatogenous Retinal Detachment. Int. J. Mol. Sci. 2023, 24, 3032. https://doi.org/10.3390/ijms24033032

AMA Style

Carpineto P, Di Filippo ES, Aharrh Gnama A, Bondi D, Iafigliola C, Licata AM, Fulle S. MicroRNA Expression in Subretinal Fluid in Eyes Affected by Rhegmatogenous Retinal Detachment. International Journal of Molecular Sciences. 2023; 24(3):3032. https://doi.org/10.3390/ijms24033032

Chicago/Turabian Style

Carpineto, Paolo, Ester Sara Di Filippo, Agbeanda Aharrh Gnama, Danilo Bondi, Carla Iafigliola, Arturo Maria Licata, and Stefania Fulle. 2023. "MicroRNA Expression in Subretinal Fluid in Eyes Affected by Rhegmatogenous Retinal Detachment" International Journal of Molecular Sciences 24, no. 3: 3032. https://doi.org/10.3390/ijms24033032

APA Style

Carpineto, P., Di Filippo, E. S., Aharrh Gnama, A., Bondi, D., Iafigliola, C., Licata, A. M., & Fulle, S. (2023). MicroRNA Expression in Subretinal Fluid in Eyes Affected by Rhegmatogenous Retinal Detachment. International Journal of Molecular Sciences, 24(3), 3032. https://doi.org/10.3390/ijms24033032

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