Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction

Li, Wang; Shu, Xinyu; Zhang, Xiaoyu; Zhang, Ziliang; Sun, Shujin; Li, Ning; Long, Mian

doi:10.3390/ijms24032197

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Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction

by

Wang Li

^1,2,

Xinyu Shu

^1,2,

Xiaoyu Zhang

^1,2,

Ziliang Zhang

¹,

Shujin Sun

^1,2,

Ning Li

^1,2,* and

Mian Long

^1,2,*

¹

Center for Biomechanics and Bioengineering, Beijing Key Laboratory of Engineered Construction and Mechanobiology and Key Laboratory of Microgravity (National Microgravity Laboratory), Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China

²

School of Engineering Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(3), 2197; https://doi.org/10.3390/ijms24032197

Submission received: 11 December 2022 / Revised: 16 January 2023 / Accepted: 19 January 2023 / Published: 22 January 2023

(This article belongs to the Special Issue Molecular Mechanobiology in Space and on Earth 2.0)

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Abstract

Microgravity exposure during spaceflight causes the disordered regulation of liver function, presenting a specialized mechano-biological coupling process. While YAP/TAZ serves as a typical mechanosensitive pathway involved in hepatocyte metabolism, it remains unclear whether and how it is correlated with microgravity-induced liver dysfunction. Here, we discussed liver function alterations induced by spaceflight or simulated effects of microgravity on Earth. The roles of YAP/TAZ serving as a potential bridge in connecting liver metabolism with microgravity were specifically summarized. Existing evidence indicated that YAP/TAZ target gene expressions were affected by mechanotransductive pathways and phase separation, reasonably speculating that microgravity might regulate YAP/TAZ activation by disrupting these pathways via cytoskeletal remodeling or nuclear deformation, or disturbing condensates formation via diffusion limit, and then breaking liver homeostasis.

Keywords: microgravity; liver metabolism; mechanosensing; cytoskeleton; nuclear deformation; phase separation

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MDPI and ACS Style

Li, W.; Shu, X.; Zhang, X.; Zhang, Z.; Sun, S.; Li, N.; Long, M. Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction. Int. J. Mol. Sci. 2023, 24, 2197. https://doi.org/10.3390/ijms24032197

AMA Style

Li W, Shu X, Zhang X, Zhang Z, Sun S, Li N, Long M. Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction. International Journal of Molecular Sciences. 2023; 24(3):2197. https://doi.org/10.3390/ijms24032197

Chicago/Turabian Style

Li, Wang, Xinyu Shu, Xiaoyu Zhang, Ziliang Zhang, Shujin Sun, Ning Li, and Mian Long. 2023. "Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction" International Journal of Molecular Sciences 24, no. 3: 2197. https://doi.org/10.3390/ijms24032197

APA Style

Li, W., Shu, X., Zhang, X., Zhang, Z., Sun, S., Li, N., & Long, M. (2023). Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction. International Journal of Molecular Sciences, 24(3), 2197. https://doi.org/10.3390/ijms24032197

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction

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