How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?
Abstract
:1. Introduction
2. Materials and Methods
Search Strategy, Study Selection, and Data Extraction
3. Diversity of Oral Microbiota and Its Interaction with the Immune System
4. Complications in Dental Implantology: Understanding the Interplay between the Immune System and Oral Microbiota Dysbiosis
4.1. Types of Treatments and Composition of Implants Used in Dentistry
- Enhanced osseointegration: To promote a faster and stronger bond between the implant and the jawbone, increasing implant stability and durability.
- Reduced healing time: Modifications can speed up the healing process, allowing for faster recovery and a shorter time to final reconstruction.
- Infection prevention: Modifications to incorporate antimicrobial properties are intended to reduce the risk of infections that may lead to implant failure.
- Improved biocompatibility: Surface modifications can increase the acceptance of the implant by surrounding tissues, reducing the risk of rejection.
- Improved aesthetics: Some modifications are intended to improve the appearance of implants, especially in visible areas of the mouth.
- Personalization: Customizing the implant to better fit the patient’s anatomy and specific clinical needs.
4.2. The Critical Role of the Immune System in the Osseointegration Process of Dental Implants
- Promotion of healing: After implantation, the immune system facilitates the healing of wounds at the site of implantation.
- Prevention of infections: Helps prevent potential infections that could interfere with the osseointegration process.
- Regulation of inflammation: Controlled inflammation is essential for osseointegration, but excessive inflammation can lead to implant failure.
- Supporting bone remodeling: Immune cells such as macrophages and osteoclasts are involved in bone remodeling, which is necessary for the integration of the implant with existing bone.
- The immune system plays a crucial role in maintaining homeostasis by regulating the balance between bone formation and resorption, a fundamental factor for implant stability. Numerous immune cells are engaged in these processes, including macrophages, neutrophils, osteoclasts, osteoblasts, dendritic cells, as well as T and B lymphocytes (Figure 8).
4.3. Types of Complications Observed in Dental Implantology and Etiology of Dental Failures
4.4. The Role of Oral Microbiota and the Immune System in the Course of Peri-Implantitis
5. Methods of Preventing Failures in Dental Implantology
5.1. Enhancing Dental Implant Safety: Strategies for Minimizing Bacterial Adhesion and Infection Risk through Material Modifications
5.2. Use of Probiotic Therapy
5.3. The Importance of Selected Nutrients in the Osseointegration Process
6. Discussion
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Rahnama-Hezavah, M.; Mertowska, P.; Mertowski, S.; Skiba, J.; Krawiec, K.; Łobacz, M.; Grywalska, E. How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems? Int. J. Mol. Sci. 2023, 24, 17620. https://doi.org/10.3390/ijms242417620
Rahnama-Hezavah M, Mertowska P, Mertowski S, Skiba J, Krawiec K, Łobacz M, Grywalska E. How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems? International Journal of Molecular Sciences. 2023; 24(24):17620. https://doi.org/10.3390/ijms242417620
Chicago/Turabian StyleRahnama-Hezavah, Mansur, Paulina Mertowska, Sebastian Mertowski, Julia Skiba, Karol Krawiec, Michał Łobacz, and Ewelina Grywalska. 2023. "How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?" International Journal of Molecular Sciences 24, no. 24: 17620. https://doi.org/10.3390/ijms242417620