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by
  • Jesús Machuca-Aguado1,
  • Antonio Félix Conde-Martín1 and
  • Alejandro Alvarez-Muñoz1
  • et al.

Reviewer 1: Anonymous Reviewer 2: Anonymous

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The present Article, ijms-2685419, entitled: (MACHINE LEARNING QUANTIFICATION OF INTRAEPI-THELIAL TUMOR-INFILTRATING LYMPHOCYTES AS A SIGNIFICANT PROGNOSTIC FACTOR IN HIGH-GRADE SEROUS OVARIAN CARCINOMAS)

The Research article is very informative and written in a very concise way. However, I have the following minor comments:

-        -  p value need to be italic along the whole manuscript.

-          -Numbers below figures (2-4) cannot be seen.

-      -Authors need to follow journal format to quite references inside text and in the journal list.

-         - Is it possible to state the precision % of the applied method???

Comments on the Quality of English Language

Minor editing of English language required

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The manuscript is very interesting but presents some points that must be improved. Figures must be improved while tables are clear. My comments are listed below: 

Introduction: It deserves to be pointed out that ovarian cancer recurrence is mainly due to the occurrence of chemotherapy resistance. In fact, cancer cells show an increased antioxidant responce (see PMID: 37175546 ) allowing a protection from platinum-derived drugs.

Figure 2 and 3: Images quality is very low and must be improved

Figures: remove the figure number (e.g. "Figure 1" from the image since it is already written in the legend

A table with the clinico-demographic characteristics of patients must be added

An accurate revision of typing errors is recommended

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

the manuscript has been significantly improved and can be accepted in the present form