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Volume 24
Issue 2
10.3390/ijms24021633
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Review
Peer-Review Record

Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?

Int. J. Mol. Sci. 2023, 24(2), 1633; https://doi.org/10.3390/ijms24021633
by Qihui Guan †, Renata Voltolini Velho †, Jalid Sehouli and Sylvia Mechsner *
Reviewer 1:
Mojtaba Moradi
Reviewer 2:
Sridhar Vemulapalli
Int. J. Mol. Sci. 2023, 24(2), 1633; https://doi.org/10.3390/ijms24021633
Submission received: 12 December 2022 / Revised: 4 January 2023 / Accepted: 10 January 2023 / Published: 13 January 2023
(This article belongs to the Special Issue Recent Advances in Endometriosis Pathophysiology and Pharmacological Treatment)

Round 1

Reviewer 1 Report

The manuscript " Endometriosis and Opioid receptors: Are opioids a possible/good treatment for endometriosis?" was found to be of potential significance. The discussion is interesting and relevant to the field, especially endometriosis-related pain which is critically imperative for endometriosis patients. Nevertheless, there are some comments and suggestions listed below for the authors.

 

Title:

Please change it to: "Endometriosis and Opioid receptors: Are opioids a possible/promising treatment for endometriosis-related pain?”

 

Abstract:

The overall conclusion of the study should be summarized and added to this section.

Keywords:

Try to avoid repeating words used in the title. Keywords are used in databases to search for research; using different words increases the probability of your work being found.

 

Introduction:

The introduction does not provide a clear rationale concerning the goals and hypotheses of the study. Please provide more details on the main aims of the study and a short background in the introduction section.

 

Body:

It would be helpful to add a separate section devoted to how analgesics, especially opioids, affect infertility and reproduction in endometriosis patients and animal models.

 

Conclusion:

 

Even though the different parts of the study have been well summarized, a more accurate and specific conclusion could enhance the quality of the study.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The authors focused on  Endometriosis and Opioid receptors. It was well written and explained review.

However, I would like to suggest adding the current efforts and challenges in developing opioids and how they can be a better target in the treatment of endometriosis would be of great value to this Review.

Adding on opioid addiction would also further enhance this review 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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