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Volume 24
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Review

Pretreated Mesenchymal Stem Cells and Their Secretome: Enhanced Immunotherapeutic Strategies

by
Yuran Su
1,
Chenyu Xu
2,
Wen Cheng
2,
Yanmei Zhao
3,
Lei Sui
1,* and
Yanhong Zhao
2,*
1
Department of Prosthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China
2
Department of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China
3
Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin 30070, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(2), 1277; https://doi.org/10.3390/ijms24021277
Submission received: 14 November 2022 / Revised: 24 December 2022 / Accepted: 28 December 2022 / Published: 9 January 2023
(This article belongs to the Section Molecular Biology)
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Abstract

Mesenchymal stem cells (MSCs) with self-renewing, multilineage differentiation and immunomodulatory properties, have been extensively studied in the field of regenerative medicine and proved to have significant therapeutic potential in many different pathological conditions. The role of MSCs mainly depends on their paracrine components, namely secretome. However, the components of MSC-derived secretome are not constant and are affected by the stimulation MSCs are exposed to. Therefore, the content and composition of secretome can be regulated by the pretreatment of MSCs. We summarize the effects of different pretreatments on MSCs and their secretome, focusing on their immunomodulatory properties, in order to provide new insights for the therapeutic application of MSCs and their secretome in inflammatory immune diseases.
Keywords: mesenchymal stem cells; pretreatment; secretome; immuomodulation; inflammatory diseases mesenchymal stem cells; pretreatment; secretome; immuomodulation; inflammatory diseases

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MDPI and ACS Style

Su, Y.; Xu, C.; Cheng, W.; Zhao, Y.; Sui, L.; Zhao, Y. Pretreated Mesenchymal Stem Cells and Their Secretome: Enhanced Immunotherapeutic Strategies. Int. J. Mol. Sci. 2023, 24, 1277. https://doi.org/10.3390/ijms24021277

AMA Style

Su Y, Xu C, Cheng W, Zhao Y, Sui L, Zhao Y. Pretreated Mesenchymal Stem Cells and Their Secretome: Enhanced Immunotherapeutic Strategies. International Journal of Molecular Sciences. 2023; 24(2):1277. https://doi.org/10.3390/ijms24021277

Chicago/Turabian Style

Su, Yuran, Chenyu Xu, Wen Cheng, Yanmei Zhao, Lei Sui, and Yanhong Zhao. 2023. "Pretreated Mesenchymal Stem Cells and Their Secretome: Enhanced Immunotherapeutic Strategies" International Journal of Molecular Sciences 24, no. 2: 1277. https://doi.org/10.3390/ijms24021277

APA Style

Su, Y., Xu, C., Cheng, W., Zhao, Y., Sui, L., & Zhao, Y. (2023). Pretreated Mesenchymal Stem Cells and Their Secretome: Enhanced Immunotherapeutic Strategies. International Journal of Molecular Sciences, 24(2), 1277. https://doi.org/10.3390/ijms24021277

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