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Article

Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm

by
Daniel Zalewski
1,*,
Paulina Chmiel
1,
Przemysław Kołodziej
1,
Grzegorz Borowski
2,
Marcin Feldo
2,†,
Janusz Kocki
3,† and
Anna Bogucka-Kocka
1,†
1
Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chodźki St., 20-093 Lublin, Poland
2
Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, 11 Staszica St., 20-081 Lublin, Poland
3
Department of Clinical Genetics, Chair of Medical Genetics, Medical University of Lublin, 11 Radziwiłłowska St., 20-080 Lublin, Poland
*
Author to whom correspondence should be addressed.
†
M.F., J.K. and A.B.-K. shared senior authorship.
Int. J. Mol. Sci. 2023, 24(15), 12087; https://doi.org/10.3390/ijms241512087
Submission received: 29 June 2023 / Revised: 21 July 2023 / Accepted: 26 July 2023 / Published: 28 July 2023
(This article belongs to the Special Issue Molecular Mechanisms, Pathogenesis, and Novel Therapeutic Strategies in Cardiovascular Disease)
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Abstract

Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed disease and is burdened with a high mortality rate (65–85%) from AAA rupture. Studies indicate that abnormal regulation of angiogenesis and inflammation contributes to progression and onset of this disease; however, dysregulations in the molecular pathways associated with this disease are not yet fully explained. Therefore, in our study, we aimed to identify dysregulations in the key regulators of angiogenesis and inflammation in patients with AAA in peripheral blood mononuclear cells (using qPCR) and plasma samples (using ELISA). Expression levels of ANGPT1, CXCL8, PDGFA, TGFB1, VEGFB, and VEGFC and plasma levels of TGF-alpha, TGF-beta 1, VEGF-A, and VEGF-C were found to be significantly altered in the AAA group compared to the control subjects without AAA. Associations between analyzed factors and risk factors or biochemical parameters were also explored. Any of the analyzed factors was associated with the size of the aneurysm. The presented study identified dysregulations in key angiogenesis- and inflammation-related factors potentially involved in AAA formation, giving new insight into the molecular pathways involved in the development of this disease and providing candidates for biomarkers that could serve as diagnostic or therapeutic targets.
Keywords: angiogenesis; inflammation; gene expression; abdominal aortic aneurysm angiogenesis; inflammation; gene expression; abdominal aortic aneurysm

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MDPI and ACS Style

Zalewski, D.; Chmiel, P.; Kołodziej, P.; Borowski, G.; Feldo, M.; Kocki, J.; Bogucka-Kocka, A. Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm. Int. J. Mol. Sci. 2023, 24, 12087. https://doi.org/10.3390/ijms241512087

AMA Style

Zalewski D, Chmiel P, Kołodziej P, Borowski G, Feldo M, Kocki J, Bogucka-Kocka A. Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm. International Journal of Molecular Sciences. 2023; 24(15):12087. https://doi.org/10.3390/ijms241512087

Chicago/Turabian Style

Zalewski, Daniel, Paulina Chmiel, Przemysław Kołodziej, Grzegorz Borowski, Marcin Feldo, Janusz Kocki, and Anna Bogucka-Kocka. 2023. "Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm" International Journal of Molecular Sciences 24, no. 15: 12087. https://doi.org/10.3390/ijms241512087

APA Style

Zalewski, D., Chmiel, P., Kołodziej, P., Borowski, G., Feldo, M., Kocki, J., & Bogucka-Kocka, A. (2023). Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm. International Journal of Molecular Sciences, 24(15), 12087. https://doi.org/10.3390/ijms241512087

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