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Article
Peer-Review Record

Relevance of Biomarkers in Serum vs. Synovial Fluid in Patients with Knee Osteoarthritis

Int. J. Mol. Sci. 2023, 24(11), 9483; https://doi.org/10.3390/ijms24119483
by Stefania Kalogera 1,2, Mylène P. Jansen 3, Anne-Christine Bay-Jensen 1, Peder Frederiksen 1, Morten A. Karsdal 1, Christian S. Thudium 1,* and Simon C. Mastbergen 3,4
Reviewer 1:
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(11), 9483; https://doi.org/10.3390/ijms24119483
Submission received: 29 April 2023 / Revised: 25 May 2023 / Accepted: 26 May 2023 / Published: 30 May 2023
(This article belongs to the Special Issue New Molecular Mechanisms and Markers in Inflammatory Disorders)

Round 1

Reviewer 1 Report

The paper is well done and properly developed.Also if the results are not definitive they are extremely useful in order to select the proper essays to better define the OA process.

Author Response

"Please see the attachment."

Author Response File: Author Response.pdf

Reviewer 2 Report

Dear Authors,

I have read with interest Your article entitled "Relevance of biomarkers in serum vs synovial fluid in patients with knee osteoarthritis". In my opinion, the article elaborates on an interesting topic and it is clear and concisely written. Although, I feel some shortcomings in the Introduction section, where between lines 51-80 it seems to me to be only a pile-up of information, fairly known by readers specialized in this field of research. I would recommend reviewing this section by the Authors by shortening these general definitions and completing/focusing mainly on articles that have assessed (even separately) the levels of these biomarkers in the serum and synovial fluid and from this information guide the reader why the present study was relevant to conduct.

Kind regards

Author Response

"Please see the attachment."

Author Response File: Author Response.pdf

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