Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells
Abstract
:1. Introduction
1.1. Caveolae, Caveolin-1 and Atherosclerosis
1.2. Cav-1 and LDL Uptake
Endothelial Cell Function | Role of Caveolin-1 | References |
---|---|---|
eNOS Activity | Interaction between eNOS and Cav-1 results in inactivation of eNOS | [23,24,25,26] |
Autophagy | Cav-1 affects expression of LC3BII | [31,32] |
Cav-1 affects intracellular localization of ATG5 | ||
Absence of Cav-1 promotes autophagy | ||
Cholesterol Control | Cav-1 is involved in cholesterol exchange between lipoproteins and plasma membrane | [34,35] |
Cav-1 may regulate intracellular cholesterol levels by mediating LDL endocytosis | ||
Cav-1 mediates transport of cholesterol from ER to plasma membrane | ||
Senescence | Cav-1 expression is increased in senescent cells. Cav-1 is involved in degradation of LDLR | [45,46] |
LDLs Trafficking | Rise in Cav-1 expression increases oxidative stress and vascular permeability | [46,47,48,49,50,59] |
Cav-1 is involved in endocytosis and transcytosis of LDLs | ||
Cav-1 is involved in degradation of LDLR |
1.3. Cav-1 and LDL Metabolism
1.4. Cav-1 and LDL Transcytosis
2. Conclusions
3. Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Puddu, A.; Montecucco, F.; Maggi, D. Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells. Int. J. Mol. Sci. 2023, 24, 8869. https://doi.org/10.3390/ijms24108869
Puddu A, Montecucco F, Maggi D. Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells. International Journal of Molecular Sciences. 2023; 24(10):8869. https://doi.org/10.3390/ijms24108869
Chicago/Turabian StylePuddu, Alessandra, Fabrizio Montecucco, and Davide Maggi. 2023. "Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells" International Journal of Molecular Sciences 24, no. 10: 8869. https://doi.org/10.3390/ijms24108869