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Article

Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice

by
Hyo Lim Lee
1,
Jong Min Kim
1,
Jong Hyun Moon
1,
Min Ji Kim
1,
Hye Rin Jeong
1,
Min Ji Go
1,
Hyun-Jin Kim
1,
Hyun Ji Eo
2,
Uk Lee
2 and
Ho Jin Heo
1,*
1
Division of Applied Life Science (BK21), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea
2
Division of Special Forest Resources, Department of Forest Bioresources, National Institute of Forest Science (NIFoS), Suwon 16631, Republic of Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(1), 90; https://doi.org/10.3390/ijms24010090
Submission received: 16 November 2022 / Revised: 12 December 2022 / Accepted: 16 December 2022 / Published: 21 December 2022
(This article belongs to the Special Issue Chronic Inflammation and Related Diseases: From Mechanisms to Therapies)
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Abstract

This study was conducted to compare the synbiotic activity between Corni fructus (C. fructus) and Limosilactobacillus reuteri (L. reuteri) on dextran sulfate sodium (DSS)-induced colitis and cognitive dysfunction in C57BL/6 mice. C. fructus (as prebiotics, PRE), L. reuteri (as probiotics, PRO), and synbiotics (as a mixture of L. reuteri and C. fructus, SYN) were fed to mice for 3 weeks. Consumption of PRE, PRO, and SYN ameliorated colitis symptoms in body weight, large intestinal length, and serum albumin level. Moreover, SYN showed a synergistic effect on intestinal permeability and intestinal anti-inflammation response. Also, SYN significantly improved cognitive function as a result of measuring the Y-maze and passive avoidance tests in DSS-induced behavioral disorder mice. Especially, SYN also restored memory function by increasing the cholinergic system and reducing tau and amyloid β pathology. In addition, PRE, PRO, and SYN ameliorated dysbiosis by regulating the gut microbiota and the concentration of short-chain fatty acids (SCFAs) in feces. The bioactive compounds of C. fructus were identified with quinic acid, morroniside, loganin, and cornuside, using ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS2). In conclusion, synbiotic supplementation alleviated DSS-induced colitis and cognitive dysfunction by modulating gut microbiota, proinflammatory cytokines, and SCFAs production.
Keywords: Corni fuctus; Limosilactobacillus reuteri; cognitive impairment; gut microbiota; anti-inflammation; gut-brain axis Corni fuctus; Limosilactobacillus reuteri; cognitive impairment; gut microbiota; anti-inflammation; gut-brain axis

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MDPI and ACS Style

Lee, H.L.; Kim, J.M.; Moon, J.H.; Kim, M.J.; Jeong, H.R.; Go, M.J.; Kim, H.-J.; Eo, H.J.; Lee, U.; Heo, H.J. Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice. Int. J. Mol. Sci. 2023, 24, 90. https://doi.org/10.3390/ijms24010090

AMA Style

Lee HL, Kim JM, Moon JH, Kim MJ, Jeong HR, Go MJ, Kim H-J, Eo HJ, Lee U, Heo HJ. Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice. International Journal of Molecular Sciences. 2023; 24(1):90. https://doi.org/10.3390/ijms24010090

Chicago/Turabian Style

Lee, Hyo Lim, Jong Min Kim, Jong Hyun Moon, Min Ji Kim, Hye Rin Jeong, Min Ji Go, Hyun-Jin Kim, Hyun Ji Eo, Uk Lee, and Ho Jin Heo. 2023. "Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice" International Journal of Molecular Sciences 24, no. 1: 90. https://doi.org/10.3390/ijms24010090

APA Style

Lee, H. L., Kim, J. M., Moon, J. H., Kim, M. J., Jeong, H. R., Go, M. J., Kim, H.-J., Eo, H. J., Lee, U., & Heo, H. J. (2023). Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice. International Journal of Molecular Sciences, 24(1), 90. https://doi.org/10.3390/ijms24010090

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