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Article

Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis

Chronic Diseases Program, Institute of Health Carlos III, 28220 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Melpo Christofidou-Solomidou
Int. J. Mol. Sci. 2022, 23(9), 4921; https://doi.org/10.3390/ijms23094921
Received: 6 April 2022 / Revised: 26 April 2022 / Accepted: 27 April 2022 / Published: 28 April 2022
(This article belongs to the Collection Feature Papers in Bioactives and Nutraceuticals)
In our previous work, we evaluated the therapeutic effects of 1α,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in the context of bleomycin-induced lung fibrosis. Contrary to the expected, vitamin D supplementation increased the DNA damage expression and cellular senescence in alveolar epithelial type II cells and aggravated the overall lung pathology induced in mice by bleomycin. These effects were probably due to an alteration in the cellular DNA double-strand breaks’ repair capability. In the present work, we have evaluated the effects of two hypocalcemic vitamin D analogs (calcipotriol and paricalcitol) in the expression of DNA damage in the context of minilungs derived from human embryonic stem cells and in the cell line A549. View Full-Text
Keywords: human pluripotent stem cells; hESCs; minilungs; vitamin D; vitamin D analogs; paricalcitol; calcipotriol; lung fibrosis human pluripotent stem cells; hESCs; minilungs; vitamin D; vitamin D analogs; paricalcitol; calcipotriol; lung fibrosis
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MDPI and ACS Style

Magro-Lopez, E.; Chamorro-Herrero, I.; Zambrano, A. Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis. Int. J. Mol. Sci. 2022, 23, 4921. https://doi.org/10.3390/ijms23094921

AMA Style

Magro-Lopez E, Chamorro-Herrero I, Zambrano A. Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis. International Journal of Molecular Sciences. 2022; 23(9):4921. https://doi.org/10.3390/ijms23094921

Chicago/Turabian Style

Magro-Lopez, Esmeralda, Irene Chamorro-Herrero, and Alberto Zambrano. 2022. "Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis" International Journal of Molecular Sciences 23, no. 9: 4921. https://doi.org/10.3390/ijms23094921

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