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Volume 23
Issue 4
10.3390/ijms23042088
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Review

Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties

by
Giovanni Schepici
,
Agnese Gugliandolo
and
Emanuela Mazzon
*
IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(4), 2088; https://doi.org/10.3390/ijms23042088
Submission received: 30 December 2021 / Revised: 11 February 2022 / Accepted: 11 February 2022 / Published: 14 February 2022
(This article belongs to the Special Issue Mesenchymal Stem Cells: Immunobiology and Role in Immunomodulation and Tissue Regeneration)
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Abstract

Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal stromal cells (MSCs) therapy based on MSCs’ regenerative and immunomodulatory properties and multilinear differentiation potential. Therefore, strategies such as MSCs preconditioning are useful to improve their application to restore damaged neuronal circuits following neurological insults. This review is focused on preconditioning MSCs therapy as a potential application to major neurological diseases. The aim of our work is to summarize both the in vitro and in vivo studies that demonstrate the efficacy of MSC preconditioning on neuronal regeneration and cell survival as a possible application to neurological damage.
Keywords: mesenchymal stromal cells; preconditioning; neurological diseases; neurogenesis; transplant mesenchymal stromal cells; preconditioning; neurological diseases; neurogenesis; transplant

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MDPI and ACS Style

Schepici, G.; Gugliandolo, A.; Mazzon, E. Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties. Int. J. Mol. Sci. 2022, 23, 2088. https://doi.org/10.3390/ijms23042088

AMA Style

Schepici G, Gugliandolo A, Mazzon E. Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties. International Journal of Molecular Sciences. 2022; 23(4):2088. https://doi.org/10.3390/ijms23042088

Chicago/Turabian Style

Schepici, Giovanni, Agnese Gugliandolo, and Emanuela Mazzon. 2022. "Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties" International Journal of Molecular Sciences 23, no. 4: 2088. https://doi.org/10.3390/ijms23042088

APA Style

Schepici, G., Gugliandolo, A., & Mazzon, E. (2022). Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties. International Journal of Molecular Sciences, 23(4), 2088. https://doi.org/10.3390/ijms23042088

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