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Review

A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics

Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA
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Authors to whom correspondence should be addressed.
Academic Editor: Erik Reimhult
Int. J. Mol. Sci. 2022, 23(3), 1851; https://doi.org/10.3390/ijms23031851
Received: 31 December 2021 / Revised: 2 February 2022 / Accepted: 3 February 2022 / Published: 6 February 2022
Neurodegenerative disorders are primarily characterized by neuron loss. The most common neurodegenerative disorders include Alzheimer’s and Parkinson’s disease. Although there are several medicines currently approved for managing neurodegenerative disorders, a large majority of them only help with associated symptoms. This lack of pathogenesis-targeting therapies is primarily due to the restrictive effects of the blood–brain barrier (BBB), which keeps close to 99% of all “foreign substances” out of the brain. Since their discovery, nanoparticles have been successfully used for targeted delivery into many organs, including the brain. This review briefly describes the pathophysiology of Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis, and their current management approaches. We then highlight the major challenges of brain-drug delivery, followed by the role of nanotherapeutics for the diagnosis and treatment of various neurological disorders. View Full-Text
Keywords: nanoparticle; neurodegenerative disorder; neurogenesis; Alzheimer’s disease; Parkinson’s disease; blood–brain barrier; amyotrophic lateral sclerosis nanoparticle; neurodegenerative disorder; neurogenesis; Alzheimer’s disease; Parkinson’s disease; blood–brain barrier; amyotrophic lateral sclerosis
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MDPI and ACS Style

Lamptey, R.N.L.; Chaulagain, B.; Trivedi, R.; Gothwal, A.; Layek, B.; Singh, J. A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics. Int. J. Mol. Sci. 2022, 23, 1851. https://doi.org/10.3390/ijms23031851

AMA Style

Lamptey RNL, Chaulagain B, Trivedi R, Gothwal A, Layek B, Singh J. A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics. International Journal of Molecular Sciences. 2022; 23(3):1851. https://doi.org/10.3390/ijms23031851

Chicago/Turabian Style

Lamptey, Richard N.L., Bivek Chaulagain, Riddhi Trivedi, Avinash Gothwal, Buddhadev Layek, and Jagdish Singh. 2022. "A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics" International Journal of Molecular Sciences 23, no. 3: 1851. https://doi.org/10.3390/ijms23031851

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