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Article

Neuronal Phenotype of col4a1 and col25a1: An Intriguing Hypothesis in Vertebrates Brain Aging

by
Adele Leggieri
1,
Chiara Attanasio
1,
Antonio Palladino
2,
Paolo de Girolamo
1,
Carla Lucini
1,† and
Livia D’Angelo
1,*,†
1
Department Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy
2
Department Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(3), 1778; https://doi.org/10.3390/ijms23031778
Submission received: 10 January 2022 / Revised: 25 January 2022 / Accepted: 27 January 2022 / Published: 4 February 2022
(This article belongs to the Special Issue Neurobiology of Aging and Aging-Related Disorders)
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Abstract

Collagens are the most abundant proteins in vertebrates and constitute the major components of the extracellular matrix. Collagens play an important and multifaceted role in the development and functioning of the nervous system and undergo structural remodeling and quantitative modifications during aging. Here, we investigated the age-dependent regulation of col4a1 and col25a1 in the brain of the short-lived vertebrate Nothobranchius furzeri, a powerful model organism for aging research due to its natural fast-aging process and further characterized typical hallmarks of brain aging in this species. We showed that col4a1 and col25a1 are relatively well conserved during vertebrate evolution, and their expression significantly increases in the brain of N. furzeri upon aging. Noteworthy, we report that both col4a1 and col25a1 are expressed in cells with a neuronal phenotype, unlike what has already been documented in mammalian brain, in which only col25a1 is considered a neuronal marker, whereas col4a1 seems to be expressed only in endothelial cells. Overall, our findings encourage further investigation on the role of col4a1 and col25a1 in the biology of the vertebrate brain as well as the onset of aging and neurodegenerative diseases.
Keywords: Nothobranchius furzeri; collagens; fish; central nervous system; aging markers Nothobranchius furzeri; collagens; fish; central nervous system; aging markers

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MDPI and ACS Style

Leggieri, A.; Attanasio, C.; Palladino, A.; de Girolamo, P.; Lucini, C.; D’Angelo, L. Neuronal Phenotype of col4a1 and col25a1: An Intriguing Hypothesis in Vertebrates Brain Aging. Int. J. Mol. Sci. 2022, 23, 1778. https://doi.org/10.3390/ijms23031778

AMA Style

Leggieri A, Attanasio C, Palladino A, de Girolamo P, Lucini C, D’Angelo L. Neuronal Phenotype of col4a1 and col25a1: An Intriguing Hypothesis in Vertebrates Brain Aging. International Journal of Molecular Sciences. 2022; 23(3):1778. https://doi.org/10.3390/ijms23031778

Chicago/Turabian Style

Leggieri, Adele, Chiara Attanasio, Antonio Palladino, Paolo de Girolamo, Carla Lucini, and Livia D’Angelo. 2022. "Neuronal Phenotype of col4a1 and col25a1: An Intriguing Hypothesis in Vertebrates Brain Aging" International Journal of Molecular Sciences 23, no. 3: 1778. https://doi.org/10.3390/ijms23031778

APA Style

Leggieri, A., Attanasio, C., Palladino, A., de Girolamo, P., Lucini, C., & D’Angelo, L. (2022). Neuronal Phenotype of col4a1 and col25a1: An Intriguing Hypothesis in Vertebrates Brain Aging. International Journal of Molecular Sciences, 23(3), 1778. https://doi.org/10.3390/ijms23031778

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