Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum
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Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea
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Laboratory of Veterinary Physiology, College of Veterinary Medicine, Jeju National University, Jeju-si 63243, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Nicolas Chevalier and Charlotte Hinault-Boyer
Int. J. Mol. Sci. 2022, 23(3), 1581; https://doi.org/10.3390/ijms23031581
Received: 11 December 2021
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Revised: 19 January 2022
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Accepted: 27 January 2022
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Published: 29 January 2022
(This article belongs to the Special Issue Advances in Endocrine Disruptors)
There is growing concern regarding the health and safety issues of endocrine-disrupting chemicals (EDCs). Long-term exposure to EDCs has serious adverse health effects through both hormone-direct and hormone-indirect ways. Accordingly, some EDCs can be a pathogen and an inducer to the susceptibility of disease, even if they have a very low affinity on the estrogen receptor, or no estrogenic effect. Endoplasmic reticulum (ER) stress recently attracted attention in this research area. Because ER and ER stress could be key regulators of the EDC’s adverse effects, such as the malfunction of the organ, as well as the death, apoptosis, and proliferation of a cell. In this review, we focused on finding evidence which shows that EDCs could be a trigger for ER stress and provide specific examples of EDCs, which are known to cause ER stress currently.
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Keywords:
endocrine system; endocrine-disrupting chemical; endoplasmic reticulum; unfolded protein response
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MDPI and ACS Style
Kim, K.; Kwon, J.-S.; Ahn, C.; Jeung, E.-B. Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum. Int. J. Mol. Sci. 2022, 23, 1581. https://doi.org/10.3390/ijms23031581
AMA Style
Kim K, Kwon J-S, Ahn C, Jeung E-B. Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum. International Journal of Molecular Sciences. 2022; 23(3):1581. https://doi.org/10.3390/ijms23031581
Chicago/Turabian StyleKim, Kangmin, Jin-Sook Kwon, Changhwan Ahn, and Eui-Bae Jeung. 2022. "Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum" International Journal of Molecular Sciences 23, no. 3: 1581. https://doi.org/10.3390/ijms23031581
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