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Review

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

1
Brain Cancer Department, Asu vanda Gene Industrial Research Company, Tehran 1533666398, Iran
2
Department of Biotechnology, Asu vanda Gene Industrial Research Company, Tehran 1533666398, Iran
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Biotechnology Center, Silesian University of Technology, 44-100 Gliwice, Poland
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Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
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Department of Pathology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
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Department of Surgery, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
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Department of Medical Microbiology and Infectious Diseases, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
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Research Institute of Oncology and Hematology, Cancer Care Manitoba, Winnipeg, MB R3E 0V9, Canada
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Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
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Faculty of Medicine, Katowice School of Technology, 40-555 Katowice, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Hau
Int. J. Mol. Sci. 2022, 23(3), 1353; https://doi.org/10.3390/ijms23031353
Received: 30 December 2021 / Revised: 14 January 2022 / Accepted: 17 January 2022 / Published: 25 January 2022
Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments, including surgery, chemotherapy, and radiation, are palliative at best. The design of effective and targeted chemotherapeutic strategies for the treatment of GBM require a thorough analysis of specific signaling pathways to identify those serving as drivers of GBM progression and invasion. The Wnt/β-catenin and PI3K/Akt/mTOR (PAM) signaling pathways are key regulators of important biological functions that include cell proliferation, epithelial–mesenchymal transition (EMT), metabolism, and angiogenesis. Targeting specific regulatory components of the Wnt/β-catenin and PAM pathways has the potential to disrupt critical brain tumor cell functions to achieve critical advancements in alternative GBM treatment strategies to enhance the survival rate of GBM patients. In this review, we emphasize the importance of the Wnt/β-catenin and PAM pathways for GBM invasion into brain tissue and explore their potential as therapeutic targets. View Full-Text
Keywords: glioblastoma; Wnt/β-catenin; PI3K/Akt/mTOR; autophagy; GBM survival glioblastoma; Wnt/β-catenin; PI3K/Akt/mTOR; autophagy; GBM survival
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MDPI and ACS Style

Barzegar Behrooz, A.; Talaie, Z.; Jusheghani, F.; Łos, M.J.; Klonisch, T.; Ghavami, S. Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma. Int. J. Mol. Sci. 2022, 23, 1353. https://doi.org/10.3390/ijms23031353

AMA Style

Barzegar Behrooz A, Talaie Z, Jusheghani F, Łos MJ, Klonisch T, Ghavami S. Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma. International Journal of Molecular Sciences. 2022; 23(3):1353. https://doi.org/10.3390/ijms23031353

Chicago/Turabian Style

Barzegar Behrooz, Amir, Zahra Talaie, Fatemeh Jusheghani, Marek J. Łos, Thomas Klonisch, and Saeid Ghavami. 2022. "Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma" International Journal of Molecular Sciences 23, no. 3: 1353. https://doi.org/10.3390/ijms23031353

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