Neomycin, but Not Neamine, Blocks Angiogenic Factor Induced Nitric Oxide Release through Inhibition of Akt Phosphorylation
Abstract
:1. Introduction
2. Results
2.1. Description of the Electrochemical Assays
2.2. Neomycin Blocks eNOS Phosphorylation after Exposure to VEGF
2.3. The Activation of Akt Is Inhibited by Neomycin, Not by Neamine
2.4. Neamine Does Not Inhibit ANG Evoked NO Release
3. Discussion
4. Materials and Methods
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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Trouillon, R.; Kang, D.-K.; Chang, S.-I.; O’Hare, D. Neomycin, but Not Neamine, Blocks Angiogenic Factor Induced Nitric Oxide Release through Inhibition of Akt Phosphorylation. Int. J. Mol. Sci. 2022, 23, 15277. https://doi.org/10.3390/ijms232315277
Trouillon R, Kang D-K, Chang S-I, O’Hare D. Neomycin, but Not Neamine, Blocks Angiogenic Factor Induced Nitric Oxide Release through Inhibition of Akt Phosphorylation. International Journal of Molecular Sciences. 2022; 23(23):15277. https://doi.org/10.3390/ijms232315277
Chicago/Turabian StyleTrouillon, Raphaël, Dong-Ku Kang, Soo-Ik Chang, and Danny O’Hare. 2022. "Neomycin, but Not Neamine, Blocks Angiogenic Factor Induced Nitric Oxide Release through Inhibition of Akt Phosphorylation" International Journal of Molecular Sciences 23, no. 23: 15277. https://doi.org/10.3390/ijms232315277