Evolution of Treatment in Advanced Cholangiocarcinoma: Old and New towards Precision Oncology
Abstract
:1. Introduction
2. The Chemotherapy Treatment for Advanced CCA
3. Targeting FGFRs in CCA
4. Targeting IDH-1/2 in CCA
5. Inhibition of BRAF p.V600E in CCA
6. NTRK Fusions: Role in CCAs
7. HER2 Amplification in CCA
8. Overview of Target-Oriented Drugs in CCA
9. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Acronym | Full Name | Incidence (%) |
---|---|---|
APC | Adenomatous polyposis coli | 15 |
ARID1A | AT-rich interaction domain 1A | 25 |
AKT1 | Homologue retrovirus kinase isolated from AKT-8(-1) | <5 |
AXIN1 | Axis inhibition protein 1 | 40 |
BAP1 | BRCA1-associated protein 1 | 25 |
BRAF | v-raf murine sarcoma viral oncogene homolog B1 | 20 |
BRCA1 | Breast Cancer gene 1 | <1 |
BRCA2 | Breast Cancer gene 2 | 3 |
CDKN2A/B | Cyclin-dependent kinase inhibitor 2A/B | 15 |
CTNNB1 | Catenin Beta 1 | 8 |
c-MET | Cellular-mesenchymal epithelial transition factor | <5 |
EGFR | Epidermal growth factor receptor | 20 |
FGFR2 | Fibroblast growth factor receptor 2 | 15 |
HER2 | Human epidermal growth factor receptor 2 | <10 |
IDH1/2 | Isocitrate dehydrogenase 1/2 | 15 |
KRAS | Kirsten rat sarcoma viral oncogene homolog | 20 |
MEK | Mapk/erk kinase | 15 |
NTRK | Neurotrophic tyrosine receptor kinase | <1 |
PIK3CA | Phosphatidylinotitol 3-kinase catalytic subunit alpha | 15 |
ROS1 | ROS proto-oncogene 1 | 10 |
SMAD4 | Mothers against decapentaplegic homolog 4 | 25 |
TP53 | Tumor protein 53 | 35 |
VEGF | Vascular endothelial growth factor | 15 |
Gene/Fusion Partner | Chromosomal Localization | Ref. |
---|---|---|
NTRK1/LMNA (Lamin A) | 1q22 | [64,67] |
NTRK1/TPM3 (Tropomyosin 3) | 1q21.3 | [64] |
NTRK1/RABGAP1L (RAB GTPase Activating Protein 1 Like) | 1q25.1 | [65,67] |
NTRK1/PLEKHA6 (Pleckstrin Homology Domain Containing A6) | 1q32.1 | [66] |
Target | Drug | Molecular Weight (Da) | Type of Inhibition | IC50 * | Most Common Clinical Toxicities (All Grades) |
---|---|---|---|---|---|
FGFR | Pemigatinib | 487.50 | Reversible | 0.5 nM/L * | Diarrhea, fatigue, alopecia, and eye tox |
Infigratinib | 560.48 | Reversible | 1.4 nM/L * | Eye tox, stomatitis, and fatigue | |
Derazantinib | 468.57 | Reversible | 1.8 nM/L * | Eye tox, stomatitis, and fatigue | |
Futibatinib | 418.45 | Irreversible | 1.4 nM/L * | Nail tox, fatigue, and musculoskeletal tox | |
IDH1 | Ivosidenib | 582.96 | Reversible | 70.0 nM/L | Diarrhea, neutropenia, leukocytosis, and fatigue |
BRAF | Vemurafenib | 482.92 | Reversible | 31 nM/L | Alopecia, arthralgia, fatigue, and eye tox |
Dabrafenib | 519.56 | Reversible | 0.7 nM/L | Fever, neutropenia, and fatigue | |
NTRK | Larotrectinib | 526.51 | Reversible | 11 nM/L ** | Anemia, fatigue, and nausea |
Entrectinib | 560.63 | Reversible | 1 nM/L ** | Dysgeusia, fatigue, and diarrhea | |
HER2 | Trastuzumab | 145,531.5 | Reversible | 1 mg/mL | Fever, nausea, allergy, and diarrhea |
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Capuozzo, M.; Santorsola, M.; Landi, L.; Granata, V.; Perri, F.; Celotto, V.; Gualillo, O.; Nasti, G.; Ottaiano, A. Evolution of Treatment in Advanced Cholangiocarcinoma: Old and New towards Precision Oncology. Int. J. Mol. Sci. 2022, 23, 15124. https://doi.org/10.3390/ijms232315124
Capuozzo M, Santorsola M, Landi L, Granata V, Perri F, Celotto V, Gualillo O, Nasti G, Ottaiano A. Evolution of Treatment in Advanced Cholangiocarcinoma: Old and New towards Precision Oncology. International Journal of Molecular Sciences. 2022; 23(23):15124. https://doi.org/10.3390/ijms232315124
Chicago/Turabian StyleCapuozzo, Maurizio, Mariachiara Santorsola, Loris Landi, Vincenza Granata, Francesco Perri, Venere Celotto, Oreste Gualillo, Guglielmo Nasti, and Alessandro Ottaiano. 2022. "Evolution of Treatment in Advanced Cholangiocarcinoma: Old and New towards Precision Oncology" International Journal of Molecular Sciences 23, no. 23: 15124. https://doi.org/10.3390/ijms232315124