Transient Receptor Potential (TRP) Channels in Tumor Vascularization
Abstract
:1. Introduction
2. Vasculogenesis, Angiogenesis, and Arteriogenesis in Neovessel Formation
3. Neovessel Formation in the Tumor
4. ECFCs in Tumor Vascularization
5. Pro-Angiogenic Ca2+ Signals in Vascular Endothelial Cells and ECFCs
6. TRP Channels
6.1. The Role of TRP Channels in Endothelial Cells
6.2. The Role of Endothelial TRP Channels in Physiological Angiogenesis
6.2.1. Role of TRPCs
6.2.2. Role of TRPVs
6.2.3. Role of TRPMs
7. The Role of Endothelial TRP Channels in Tumor Vascularization
7.1. Breast Cancer
7.2. Prostate Cancer
7.3. Renal Cellular Carcinoma
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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TRPC Subunit | Angiogenic Processes Regulated |
---|---|
TRPC1/TRPC4/TRPC3/TRPC5/TRPC6 | Proliferation, migration, in vitro tubulogenesis. |
TRPC1 | Filipodia extension, motility in vivo (sprouting angiogenesis); ECFC and MAC proliferation and tube formation. |
TRPC4 | Retinal neovascularization. |
TRPC6 | Wound closure in vitro and carotid artery regeneration in vivo. |
TRPC5 | Neovascularization in hypoxic retina and in mouse hindlimb ischemia. Negative modulation of migration and wound closure in vitro and arterial regeneration in vivo. |
TRP Subunit | Angiogenic Processes Regulated |
---|---|
TRPV1 | Proliferation, migration and tube formation in vitro, angiogenesis in vivo. |
TRPV4 | Proliferation, migration, tube formation in vitro, angiogenesis and arteriogenesis in vivo, ECFC proliferation. |
TRP Subunit | Angiogenic Processes Regulated |
---|---|
TRPM2 | Migration in vitro, neovascularization in vivo. |
TRPM4 | Negative regulation of in vitro tubulogenesis and in vivo angiogenesis; supports H2O2-induced migration. |
TRPM7 | Negative regulation of HUVEC proliferation, adhesion, and migration in vitro and tubulogenesis in vivo; positive regulation of HMEC proliferation and migration. |
TRPA1 | Tube formation in vitro and neovascularization upon corneal cauterization in vivo. |
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Perna, A.; Sellitto, C.; Komici, K.; Hay, E.; Rocca, A.; De Blasiis, P.; Lucariello, A.; Moccia, F.; Guerra, G. Transient Receptor Potential (TRP) Channels in Tumor Vascularization. Int. J. Mol. Sci. 2022, 23, 14253. https://doi.org/10.3390/ijms232214253
Perna A, Sellitto C, Komici K, Hay E, Rocca A, De Blasiis P, Lucariello A, Moccia F, Guerra G. Transient Receptor Potential (TRP) Channels in Tumor Vascularization. International Journal of Molecular Sciences. 2022; 23(22):14253. https://doi.org/10.3390/ijms232214253
Chicago/Turabian StylePerna, Angelica, Carmine Sellitto, Klara Komici, Eleonora Hay, Aldo Rocca, Paolo De Blasiis, Angela Lucariello, Francesco Moccia, and Germano Guerra. 2022. "Transient Receptor Potential (TRP) Channels in Tumor Vascularization" International Journal of Molecular Sciences 23, no. 22: 14253. https://doi.org/10.3390/ijms232214253