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Review

Peripheral Nerve Injury Treatments and Advances: One Health Perspective

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Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401 Porto, Portugal
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Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal
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Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal
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CECAV, Centre for Animal Sciences and Veterinary Studies, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Barbara Zavan
Int. J. Mol. Sci. 2022, 23(2), 918; https://doi.org/10.3390/ijms23020918
Received: 29 December 2021 / Revised: 9 January 2022 / Accepted: 11 January 2022 / Published: 14 January 2022
Peripheral nerve injuries (PNI) can have several etiologies, such as trauma and iatrogenic interventions, that can lead to the loss of structure and/or function impairment. These changes can cause partial or complete loss of motor and sensory functions, physical disability, and neuropathic pain, which in turn can affect the quality of life. This review aims to revisit the concepts associated with the PNI and the anatomy of the peripheral nerve is detailed to explain the different types of injury. Then, some of the available therapeutic strategies are explained, including surgical methods, pharmacological therapies, and the use of cell-based therapies alone or in combination with biomaterials in the form of tube guides. Nevertheless, even with the various available treatments, it is difficult to achieve a perfect outcome with complete functional recovery. This review aims to enhance the importance of new therapies, especially in severe lesions, to overcome limitations and achieve better outcomes. The urge for new approaches and the understanding of the different methods to evaluate nerve regeneration is fundamental from a One Health perspective. In vitro models followed by in vivo models are very important to be able to translate the achievements to human medicine. View Full-Text
Keywords: mesenchymal stem cells; nerve guide conduits; nerve recovery; one health; peripheral nerve injury; secretome mesenchymal stem cells; nerve guide conduits; nerve recovery; one health; peripheral nerve injury; secretome
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MDPI and ACS Style

Lopes, B.; Sousa, P.; Alvites, R.; Branquinho, M.; Sousa, A.C.; Mendonça, C.; Atayde, L.M.; Luís, A.L.; Varejão, A.S.P.; Maurício, A.C. Peripheral Nerve Injury Treatments and Advances: One Health Perspective. Int. J. Mol. Sci. 2022, 23, 918. https://doi.org/10.3390/ijms23020918

AMA Style

Lopes B, Sousa P, Alvites R, Branquinho M, Sousa AC, Mendonça C, Atayde LM, Luís AL, Varejão ASP, Maurício AC. Peripheral Nerve Injury Treatments and Advances: One Health Perspective. International Journal of Molecular Sciences. 2022; 23(2):918. https://doi.org/10.3390/ijms23020918

Chicago/Turabian Style

Lopes, Bruna, Patrícia Sousa, Rui Alvites, Mariana Branquinho, Ana C. Sousa, Carla Mendonça, Luís M. Atayde, Ana L. Luís, Artur S.P. Varejão, and Ana C. Maurício. 2022. "Peripheral Nerve Injury Treatments and Advances: One Health Perspective" International Journal of Molecular Sciences 23, no. 2: 918. https://doi.org/10.3390/ijms23020918

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