Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair

Qin, Qiuyue; Liu, Yiping; Yang, Zhen; Aimaijiang, Maierhaba; Ma, Rui; Yang, Yixin; Zhang, Yidi; Zhou, Yanmin

doi:10.3390/ijms231911201

Open AccessReview

Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair

by

Qiuyue Qin

,

Yiping Liu

,

Zhen Yang

,

Maierhaba Aimaijiang

,

Rui Ma

,

Yixin Yang

,

Yidi Zhang

^* and

Yanmin Zhou

^*

Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun 130021, China

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2022, 23(19), 11201; https://doi.org/10.3390/ijms231911201

Submission received: 8 August 2022 / Revised: 10 September 2022 / Accepted: 14 September 2022 / Published: 23 September 2022

(This article belongs to the Special Issue Advance in Bone Biology)

Download

Browse Figures

Versions Notes

Abstract

Sufficient oxygen is required to maintain normal cellular and physiological function, such as a creature’s development, breeding, and homeostasis. Lately, some researchers have reported that both pathological hypoxia and environmental hypoxia might affect bone health. Adaptation to hypoxia is a pivotal cellular event in normal cell development and differentiation and in pathological settings such as ischemia. As central mediators of homeostasis, hypoxia-inducible transcription factors (HIFs) can allow cells to survive in a low-oxygen environment and are essential for the regulation of osteogenesis and skeletal repair. From this perspective, we summarized the role of HIF-1 and HIF-2 in signaling pathways implicated in bone development and skeletal repair and outlined the molecular mechanism of regulation of downstream growth factors and protein molecules such as VEGF, EPO, and so on. All of these present an opportunity for developing therapies for bone regeneration.

Keywords: hypoxia-inducible factors; osteogenesis; vascular endothelial growth factors; erythropoietin; wnt

Share and Cite

MDPI and ACS Style

Qin, Q.; Liu, Y.; Yang, Z.; Aimaijiang, M.; Ma, R.; Yang, Y.; Zhang, Y.; Zhou, Y. Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair. Int. J. Mol. Sci. 2022, 23, 11201. https://doi.org/10.3390/ijms231911201

AMA Style

Qin Q, Liu Y, Yang Z, Aimaijiang M, Ma R, Yang Y, Zhang Y, Zhou Y. Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair. International Journal of Molecular Sciences. 2022; 23(19):11201. https://doi.org/10.3390/ijms231911201

Chicago/Turabian Style

Qin, Qiuyue, Yiping Liu, Zhen Yang, Maierhaba Aimaijiang, Rui Ma, Yixin Yang, Yidi Zhang, and Yanmin Zhou. 2022. "Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair" International Journal of Molecular Sciences 23, no. 19: 11201. https://doi.org/10.3390/ijms231911201

APA Style

Qin, Q., Liu, Y., Yang, Z., Aimaijiang, M., Ma, R., Yang, Y., Zhang, Y., & Zhou, Y. (2022). Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair. International Journal of Molecular Sciences, 23(19), 11201. https://doi.org/10.3390/ijms231911201

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI