A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis

Round 1

Reviewer 1 Report

The manuscript has merits for publication, pending some minor adjustments as indicated below:

Abstract: an introductory sentence should be added in order to contextualize the reader.

Line 22: Replace “the last” with “the latter.”

Introduction: More background information on the use of nutraceuticals to treat canine/feline OA should be added to highlight the importance of this systematic review.

Lines 37-41: Reference?

Line 60: Replace “affected with” with “affected by.”

Item 2.1: I’m surprised that terms like “bioactives,” “phytochemicals,” and other similar terms were not included in the search, as these compounds are the basis of nutraceutical development in several cases.

Lines 396-401: It is still unclear to me why omega-3 has this therapeutic effect. I believe the authors should expand a bit further on that.

Author Response

Please, see attached document

Author Response File: Author Response.docx

Reviewer 2 Report

In the present manuscript, Barbeau-Grégoire and co-workers, highlighted through a systematic review and meta-analysis studies that omega-3 enriched diets, omega-3 supplements and cannabidiol are the most effective analgesics in canine osteoarthritis pain management.

The article is well written and explained. I just have a recommendation:

Ø  To complete the manuscript with information regarding the ability of omega-3 to modulate the intracellular signaling pathways associated with the pain control compare to collagen or chondroitin-glucosamine nutraceuticals.

Author Response

Please, see attached document

Author Response File: Author Response.doc