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Article

Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer’s Dementia

by
Teresa Urbano
1,
Marco Vinceti
1,2,3,*,
Jessica Mandrioli
2,4,
Annalisa Chiari
4,
Tommaso Filippini
1,2,5,
Roberta Bedin
2,4,
Manuela Tondelli
2,4,
Cecilia Simonini
2,4,
Giovanna Zamboni
2,4,
Misaki Shimizu
6 and
Yoshiro Saito
6
1
CREAGEN—Environmental, Genetic and Nutritional Epidemiology Research Center, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena, Italy
2
Center for Neurosciences and Neurotechnology, Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena, Italy
3
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
4
Neurology Unit, Azienda Ospedaliero Universitaria di Modena, 71 Via del Pozzo, 41121 Modena, Italy
5
School of Public Health, University of California Berkeley, 1995 University Avenue, Berkeley, CA 94704, USA
6
Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(17), 9865; https://doi.org/10.3390/ijms23179865
Submission received: 26 July 2022 / Revised: 26 August 2022 / Accepted: 27 August 2022 / Published: 30 August 2022
(This article belongs to the Special Issue Molecular Research on Amyotrophic Lateral Sclerosis)
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Abstract

Selenoprotein P, a selenium-transporter protein, has been hypothesized to play a role in the etiology of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s dementia (AD). However, data in humans are scarce and largely confined to autoptic samples. In this case–control study, we determined selenoprotein P concentrations in both the cerebrospinal fluid (CSF) and the serum of 50 individuals diagnosed with ALS, 30 with AD, 54 with mild cognitive impairment (MCI) and of 30 controls, using sandwich enzyme-linked immunosorbent assay (ELISA) methods. We found a positive and generally linear association between CSF and serum selenoprotein P concentrations in all groups. CSF selenoprotein P and biomarkers of neurodegeneration were positively associated in AD, while for MCI, we found an inverted-U-shaped relation. CSF selenoprotein P concentrations were higher in AD and MCI than in ALS and controls, while in serum, the highest concentrations were found in MCI and ALS. Logistic and cubic spline regression analyses showed an inverse association between CSF selenoprotein P levels and ALS risk, and a positive association for AD risk, while an inverted-U-shaped relation with MCI risk emerged. Conversely, serum selenoprotein P concentrations were positively associated with risk of all conditions but only in their lower range. Overall, these findings indicate some abnormalities of selenoprotein P concentrations in both the central nervous system and blood associated with ALS and neurocognitive disorders, though in different directions. These alterations may reflect either phenomena of etiologic relevance or disease-induced alterations of nutritional and metabolic status.
Keywords: selenium; selenoprotein P; mild cognitive impairment; dementia; amyotrophic lateral sclerosis selenium; selenoprotein P; mild cognitive impairment; dementia; amyotrophic lateral sclerosis

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MDPI and ACS Style

Urbano, T.; Vinceti, M.; Mandrioli, J.; Chiari, A.; Filippini, T.; Bedin, R.; Tondelli, M.; Simonini, C.; Zamboni, G.; Shimizu, M.; et al. Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer’s Dementia. Int. J. Mol. Sci. 2022, 23, 9865. https://doi.org/10.3390/ijms23179865

AMA Style

Urbano T, Vinceti M, Mandrioli J, Chiari A, Filippini T, Bedin R, Tondelli M, Simonini C, Zamboni G, Shimizu M, et al. Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer’s Dementia. International Journal of Molecular Sciences. 2022; 23(17):9865. https://doi.org/10.3390/ijms23179865

Chicago/Turabian Style

Urbano, Teresa, Marco Vinceti, Jessica Mandrioli, Annalisa Chiari, Tommaso Filippini, Roberta Bedin, Manuela Tondelli, Cecilia Simonini, Giovanna Zamboni, Misaki Shimizu, and et al. 2022. "Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer’s Dementia" International Journal of Molecular Sciences 23, no. 17: 9865. https://doi.org/10.3390/ijms23179865

APA Style

Urbano, T., Vinceti, M., Mandrioli, J., Chiari, A., Filippini, T., Bedin, R., Tondelli, M., Simonini, C., Zamboni, G., Shimizu, M., & Saito, Y. (2022). Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer’s Dementia. International Journal of Molecular Sciences, 23(17), 9865. https://doi.org/10.3390/ijms23179865

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