Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review

Sparić, Radmila; Andjić, Mladen; Babović, Ivana; Nejković, Lazar; Mitrović, Milena; Štulić, Jelena; Pupovac, Miljan; Tinelli, Andrea

doi:10.3390/ijms23179728

Open AccessReview

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review

by

Radmila Sparić

^1,2

,

Mladen Andjić

^1,*,

Ivana Babović

^1,2

,

Lazar Nejković

^2,3,

Milena Mitrović

^1,2,

Jelena Štulić

³,

Miljan Pupovac

¹ and

Andrea Tinelli

^4,*

¹

Clinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, Koste Todorovića 26, 11000 Belgrade, Serbia

²

Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia

³

Clinic of Gynecology and Obstetrics Narodni Front, 11000 Belgrade, Serbia

⁴

Department of Obstetrics and Gynecology, and CERICSAL (CEntro di Ricerca Clinico SALentino), “Verisdelli Ponti Hospital”, Via Giuseppina Delli Ponti, 73020 Scorrano, LE, Italy

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2022, 23(17), 9728; https://doi.org/10.3390/ijms23179728

Submission received: 3 July 2022 / Revised: 19 August 2022 / Accepted: 20 August 2022 / Published: 27 August 2022

(This article belongs to the Special Issue Molecular Research in Uterine Biology and Pathophysiology)

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Abstract

Uterine fibroids (UFs) are the most common benign tumors of female genital diseases, unlike uterine leiomyosarcoma (LMS), a rare and aggressive uterine cancer. This narrative review aims to discuss the biology and diagnosis of LMS and, at the same time, their differential diagnosis, in order to distinguish the biological and molecular origins. The authors performed a Medline and PubMed search for the years 1990–2022 using a combination of keywords on the topics to highlight the many genes and proteins involved in the pathogenesis of LMS. The mutation of these genes, in addition to the altered expression and functions of their enzymes, are potentially biomarkers of uterine LMS. Thus, the use of this molecular and protein information could favor differential diagnosis and personalized therapy based on the molecular characteristics of LMS tissue, leading to timely diagnoses and potential better outcomes for patients.

Keywords: uterine fibroid; leiomyosarcoma; molecular; gene; differential diagnosis; omics

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MDPI and ACS Style

Sparić, R.; Andjić, M.; Babović, I.; Nejković, L.; Mitrović, M.; Štulić, J.; Pupovac, M.; Tinelli, A. Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review. Int. J. Mol. Sci. 2022, 23, 9728. https://doi.org/10.3390/ijms23179728

AMA Style

Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A. Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review. International Journal of Molecular Sciences. 2022; 23(17):9728. https://doi.org/10.3390/ijms23179728

Chicago/Turabian Style

Sparić, Radmila, Mladen Andjić, Ivana Babović, Lazar Nejković, Milena Mitrović, Jelena Štulić, Miljan Pupovac, and Andrea Tinelli. 2022. "Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review" International Journal of Molecular Sciences 23, no. 17: 9728. https://doi.org/10.3390/ijms23179728

APA Style

Sparić, R., Andjić, M., Babović, I., Nejković, L., Mitrović, M., Štulić, J., Pupovac, M., & Tinelli, A. (2022). Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review. International Journal of Molecular Sciences, 23(17), 9728. https://doi.org/10.3390/ijms23179728

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Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review

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