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Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis

by and *
Department of Nephrology, School of Medicine, Tongji Hospital, Tongji University, Shanghai 200065, China
*
Author to whom correspondence should be addressed.
Academic Editors: Christos Chatziantoniou and Christos E. Chadjichristos
Int. J. Mol. Sci. 2022, 23(13), 6970; https://doi.org/10.3390/ijms23136970
Received: 1 June 2022 / Revised: 20 June 2022 / Accepted: 20 June 2022 / Published: 23 June 2022
(This article belongs to the Special Issue Molecular Mechanisms of Renal Diseases)
As an integral part of the vascular system, the lymphatic vasculature is essential for tissue fluid homeostasis, nutritional lipid assimilation and immune regulation. The composition of the lymphatic vasculature includes fluid-absorbing initial lymphatic vessels (LVs), transporting collecting vessels and anti-regurgitation valves. Although, in recent decades, research has drastically enlightened our view of LVs, investigations of initial LVs, also known as lymphatic capillaries, have been stagnant due to technical limitations. In the kidney, the lymphatic vasculature mainly presents in the cortex, keeping the local balance of fluid, solutes and immune cells. The contribution of renal LVs to various forms of pathology, especially chronic kidney diseases, has been addressed in previous studies, however with diverging and inconclusive results. In this review, we discuss the most recent advances in the proliferation and permeability of lymphatic capillaries as well as their influencing factors. Novel technologies to visualize and measure LVs function are described. Then, we highlight the role of the lymphatic network in renal fibrosis and the crosstalk between kidney and other organs, such as gut and heart. View Full-Text
Keywords: lymphatic system; permeability; lymphangiogenesis; renal fibrosis lymphatic system; permeability; lymphangiogenesis; renal fibrosis
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MDPI and ACS Style

Liu, J.; Yu, C. Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis. Int. J. Mol. Sci. 2022, 23, 6970. https://doi.org/10.3390/ijms23136970

AMA Style

Liu J, Yu C. Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis. International Journal of Molecular Sciences. 2022; 23(13):6970. https://doi.org/10.3390/ijms23136970

Chicago/Turabian Style

Liu, Jing, and Chen Yu. 2022. "Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis" International Journal of Molecular Sciences 23, no. 13: 6970. https://doi.org/10.3390/ijms23136970

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