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Review

Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide

1
Department of Molecular Biology, Faculty of Biology, University of Gdansk, 80-308 Gdansk, Poland
2
Skeletal Dysplasia Research Lab, Nemours Children’s Health, 1600 Rockland Rd., Wilmington, DE 19899, USA
3
Department of Diabetes, Endocrinology, and Nutrition, Kyoto University Hospital, Kyoto 606-8507, Japan
4
Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA 19107, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Chih-Hsin Tang
Int. J. Mol. Sci. 2022, 23(11), 5916; https://doi.org/10.3390/ijms23115916
Received: 12 April 2022 / Revised: 17 May 2022 / Accepted: 21 May 2022 / Published: 25 May 2022
(This article belongs to the Special Issue Bone Development and Growth)
The skeletal development process in the body occurs through sequential cellular and molecular processes called endochondral ossification. Endochondral ossification occurs in the growth plate where chondrocytes differentiate from resting, proliferative, hypertrophic to calcified zones. Natriuretic peptides (NPTs) are peptide hormones with multiple functions, including regulation of blood pressure, water-mineral balance, and many metabolic processes. NPTs secreted from the heart activate different tissues and organs, working in a paracrine or autocrine manner. One of the natriuretic peptides, C-type natriuretic peptide-, induces bone growth through several mechanisms. This review will summarize the knowledge, including the newest discoveries, of the mechanism of CNP activation in bone growth. View Full-Text
Keywords: natriuretic peptide; growth plate; chondrocyte cell; bone growth; molecular mechanism natriuretic peptide; growth plate; chondrocyte cell; bone growth; molecular mechanism
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MDPI and ACS Style

Rintz, E.; Węgrzyn, G.; Fujii, T.; Tomatsu, S. Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide. Int. J. Mol. Sci. 2022, 23, 5916. https://doi.org/10.3390/ijms23115916

AMA Style

Rintz E, Węgrzyn G, Fujii T, Tomatsu S. Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide. International Journal of Molecular Sciences. 2022; 23(11):5916. https://doi.org/10.3390/ijms23115916

Chicago/Turabian Style

Rintz, Estera, Grzegorz Węgrzyn, Toshihito Fujii, and Shunji Tomatsu. 2022. "Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide" International Journal of Molecular Sciences 23, no. 11: 5916. https://doi.org/10.3390/ijms23115916

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