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Volume 23
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10.3390/ijms23105757
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Article

Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation

by
Kenjiro Hayashi
1,2,
Koichi Sato
1,
Seishi Ochi
1,
Shuhei Kawano
1,
Seiichi Munesue
2,
Ai Harashima
2,
Yu Oshima
2,
Kumi Kimura
2,
Takashi Kyoi
1 and
Yasuhiko Yamamoto
2,*
1
Food Development Labs, Functional Food Division, Nippon Shinyaku Co., Ltd., Kyoto 601-8550, Japan
2
Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8640, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(10), 5757; https://doi.org/10.3390/ijms23105757
Submission received: 17 December 2021 / Revised: 19 May 2022 / Accepted: 19 May 2022 / Published: 20 May 2022
(This article belongs to the Section Biochemistry)
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Abstract

Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examined whether ethanol extracts of Saururus chinensis (Lour.) Baill. (SE) could affect RAGE signaling and vascular relaxation in streptozotocin (STZ)-induced diabetic rats. Treatment with SE inhibited AGEs-modified bovine serum albumin (AGEs-BSA)-elicited activation of NF-κB and could compete with AGEs-BSA binding to RAGE in a dose-dependent manner. Tumor necrosis factor-α (TNF-α) secretion induced by lipopolysaccharide (LPS)—a RAGE ligand—was also reduced by SE treatment in wild-type Ager+/+ mice as well as in cultured peritoneal macrophages from Ager+/+ mice but not in Ager−/− mice. SE administration significantly ameliorated diabetes-related dysregulation of acetylcholine-mediated vascular relaxation in STZ-induced diabetic rats. These results suggest that SE would inhibit RAGE signaling and would be useful for the improvement of vascular endothelial dysfunction in diabetes.
Keywords: receptor for advanced glycation end-products (RAGE); Saururus chinensis (Lour.) Baill; vascular relaxation receptor for advanced glycation end-products (RAGE); Saururus chinensis (Lour.) Baill; vascular relaxation

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MDPI and ACS Style

Hayashi, K.; Sato, K.; Ochi, S.; Kawano, S.; Munesue, S.; Harashima, A.; Oshima, Y.; Kimura, K.; Kyoi, T.; Yamamoto, Y. Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation. Int. J. Mol. Sci. 2022, 23, 5757. https://doi.org/10.3390/ijms23105757

AMA Style

Hayashi K, Sato K, Ochi S, Kawano S, Munesue S, Harashima A, Oshima Y, Kimura K, Kyoi T, Yamamoto Y. Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation. International Journal of Molecular Sciences. 2022; 23(10):5757. https://doi.org/10.3390/ijms23105757

Chicago/Turabian Style

Hayashi, Kenjiro, Koichi Sato, Seishi Ochi, Shuhei Kawano, Seiichi Munesue, Ai Harashima, Yu Oshima, Kumi Kimura, Takashi Kyoi, and Yasuhiko Yamamoto. 2022. "Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation" International Journal of Molecular Sciences 23, no. 10: 5757. https://doi.org/10.3390/ijms23105757

APA Style

Hayashi, K., Sato, K., Ochi, S., Kawano, S., Munesue, S., Harashima, A., Oshima, Y., Kimura, K., Kyoi, T., & Yamamoto, Y. (2022). Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation. International Journal of Molecular Sciences, 23(10), 5757. https://doi.org/10.3390/ijms23105757

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