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Article

Antibacterial [email protected] Loaded PVA Nanofiber Membrane for Infected Bone Repair

1
Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China
2
School of Civil and Transportation Engineering, Hebei University of Technology, Tianjin 300130, China
3
Center for Health Science and Engineering, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China
4
Fujian Provincial Key Laboratory for Advanced Micro-Nano Photonics Technology and Devices, Research Center for Photonics Technology, Quanzhou Normal University, Quanzhou 362000, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Peter Veranič
Int. J. Mol. Sci. 2022, 23(10), 5629; https://doi.org/10.3390/ijms23105629
Received: 16 April 2022 / Revised: 13 May 2022 / Accepted: 15 May 2022 / Published: 18 May 2022
(This article belongs to the Collection State-of-the-Art Materials Science in China)
Bone substitutes with strong antibacterial properties and bone regeneration effects have an inherent potential in the treatment of severe bone tissue infections, such as osteomyelitis. In this study, vancomycin (Van) was loaded into zeolitic imidazolate framework-8 (ZIF-8) to prepare composite particles, which is abbreviated as [email protected] As a pH-responsive particle, ZIF-8 can be cleaved in the weak acid environment caused by bacterial infection to realize the effective release of drugs. Then, [email protected] was loaded into polyvinyl alcohol (PVA) fiber by electrospinning to prepare PVA/[email protected] composite bone filler. The drug-loading rate of [email protected] was about 6.735%. The membranes exhibited super hydrophilicity, water absorption and pH-controlled Van release behavior. The properties of anti E. coli and S. aureus were studied under the pH conditions of normal physiological tissues and infected tissues (pH 7.4 and pH 6.5, respectively). It was found that the material had good surface antibacterial adhesion and antibacterial property. The PVA/[email protected] membrane had the more prominent bacteria-killing effect compared with the same amount of single antibacterial agent containing membrane such as ZIF-8 or Van loaded PVA, and the antibacterial rate was up to 99%. The electrospun membrane had good biocompatibility and can promote MC3T3-E1 cell spreading on it. View Full-Text
Keywords: ZIF-8; drug loading; electrospinning; antibacterial activity; cell adhesion ZIF-8; drug loading; electrospinning; antibacterial activity; cell adhesion
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MDPI and ACS Style

Zhao, Y.; Wang, H.; Zou, X.; Wang, D.; Fan, Y.; Zhao, X.; Li, M.; Yang, L.; Liang, C. Antibacterial [email protected] Loaded PVA Nanofiber Membrane for Infected Bone Repair. Int. J. Mol. Sci. 2022, 23, 5629. https://doi.org/10.3390/ijms23105629

AMA Style

Zhao Y, Wang H, Zou X, Wang D, Fan Y, Zhao X, Li M, Yang L, Liang C. Antibacterial [email protected] Loaded PVA Nanofiber Membrane for Infected Bone Repair. International Journal of Molecular Sciences. 2022; 23(10):5629. https://doi.org/10.3390/ijms23105629

Chicago/Turabian Style

Zhao, Yunbo, Hongshui Wang, Xianrui Zou, Donghui Wang, Ying Fan, Xiaoyan Zhao, Mingjun Li, Lei Yang, and Chunyong Liang. 2022. "Antibacterial [email protected] Loaded PVA Nanofiber Membrane for Infected Bone Repair" International Journal of Molecular Sciences 23, no. 10: 5629. https://doi.org/10.3390/ijms23105629

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