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Article

A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

1
Instituto de Ciencia Molecular (ICMol), Universitat de València, c/Catedrático José Beltrán 2, Paterna, 46980 Valencia, Spain
2
Radiology Department and Biomedical Imaging Research Group (GIBI230), La Fe University and Polytechnic Hospital and La Fe Health Research Institute, 46026 Valencia, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Diego Tesauro
Int. J. Mol. Sci. 2021, 22(9), 4586; https://doi.org/10.3390/ijms22094586
Received: 25 March 2021 / Revised: 19 April 2021 / Accepted: 23 April 2021 / Published: 27 April 2021
(This article belongs to the Special Issue Metal Complexes in Diagnosis and Therapy)
The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging. View Full-Text
Keywords: thymine; gadolinium; contrast agent; magnetic resonance; metal complexes; crystal structure; relaxivity thymine; gadolinium; contrast agent; magnetic resonance; metal complexes; crystal structure; relaxivity
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MDPI and ACS Style

Orts-Arroyo, M.; Ten-Esteve, A.; Ginés-Cárdenas, S.; Castro, I.; Martí-Bonmatí, L.; Martínez-Lillo, J. A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging. Int. J. Mol. Sci. 2021, 22, 4586. https://doi.org/10.3390/ijms22094586

AMA Style

Orts-Arroyo M, Ten-Esteve A, Ginés-Cárdenas S, Castro I, Martí-Bonmatí L, Martínez-Lillo J. A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging. International Journal of Molecular Sciences. 2021; 22(9):4586. https://doi.org/10.3390/ijms22094586

Chicago/Turabian Style

Orts-Arroyo, Marta, Amadeo Ten-Esteve, Sonia Ginés-Cárdenas, Isabel Castro, Luis Martí-Bonmatí, and José Martínez-Lillo. 2021. "A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging" International Journal of Molecular Sciences 22, no. 9: 4586. https://doi.org/10.3390/ijms22094586

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