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Review

What Are the Potential Roles of Nuclear Perlecan and Other Heparan Sulphate Proteoglycans in the Normal and Malignant Phenotype

by 1 and 2,3,4,5,*
1
Bioimaging Research Hub, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK
2
Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia
3
Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia
4
The Faculty of Medicine and Health, The University of Sydney, St. Leonards, NSW 2065, Australia
5
Sydney Medical School, Northern, Sydney University, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Eok-Soo Oh
Int. J. Mol. Sci. 2021, 22(9), 4415; https://doi.org/10.3390/ijms22094415
Received: 30 March 2021 / Revised: 19 April 2021 / Accepted: 19 April 2021 / Published: 23 April 2021
The recent discovery of nuclear and perinuclear perlecan in annulus fibrosus and nucleus pulposus cells and its known matrix stabilizing properties in tissues introduces the possibility that perlecan may also have intracellular stabilizing or regulatory roles through interactions with nuclear envelope or cytoskeletal proteins or roles in nucleosomal-chromatin organization that may regulate transcriptional factors and modulate gene expression. The nucleus is a mechano-sensor organelle, and sophisticated dynamic mechanoresponsive cytoskeletal and nuclear envelope components support and protect the nucleus, allowing it to perceive and respond to mechano-stimulation. This review speculates on the potential roles of perlecan in the nucleus based on what is already known about nuclear heparan sulphate proteoglycans. Perlecan is frequently found in the nuclei of tumour cells; however, its specific role in these diseased tissues is largely unknown. The aim of this review is to highlight probable roles for this intriguing interactive regulatory proteoglycan in the nucleus of normal and malignant cell types. View Full-Text
Keywords: nucleus; heparan sulphate; heparan sulphate proteoglycan; perlecan; syndecan; glypican; tensegrity nucleus; heparan sulphate; heparan sulphate proteoglycan; perlecan; syndecan; glypican; tensegrity
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MDPI and ACS Style

Hayes, A.J.; Melrose, J. What Are the Potential Roles of Nuclear Perlecan and Other Heparan Sulphate Proteoglycans in the Normal and Malignant Phenotype. Int. J. Mol. Sci. 2021, 22, 4415. https://doi.org/10.3390/ijms22094415

AMA Style

Hayes AJ, Melrose J. What Are the Potential Roles of Nuclear Perlecan and Other Heparan Sulphate Proteoglycans in the Normal and Malignant Phenotype. International Journal of Molecular Sciences. 2021; 22(9):4415. https://doi.org/10.3390/ijms22094415

Chicago/Turabian Style

Hayes, Anthony J., and James Melrose. 2021. "What Are the Potential Roles of Nuclear Perlecan and Other Heparan Sulphate Proteoglycans in the Normal and Malignant Phenotype" International Journal of Molecular Sciences 22, no. 9: 4415. https://doi.org/10.3390/ijms22094415

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