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Article

A Photoresponsive Artificial Viral Capsid Self-Assembled from an Azobenzene-Containing β-Annulus Peptide

1
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
2
Centre for Research on Green Sustainable Chemistry, Tottori University, Tottori 680-8552, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Antonio Rosato
Int. J. Mol. Sci. 2021, 22(8), 4028; https://doi.org/10.3390/ijms22084028
Received: 24 March 2021 / Revised: 11 April 2021 / Accepted: 12 April 2021 / Published: 14 April 2021
(This article belongs to the Special Issue Self-Assembly Mechanism and Connection of Peptides and Proteins)
Photoinduced structural changes in peptides can dynamically control the formation and dissociation of supramolecular peptide materials. However, the existence of photoresponsive viral capsids in nature remains unknown. In this study, we constructed an artificial viral capsid possessing a photochromic azobenzene moiety on the peptide backbone. An azobenzene-containing β-annulus peptide derived from the tomato bushy stunt virus was prepared through solid-phase synthesis using Fmoc-3-[(3-aminomethyl)-phenylazo]phenylacetic acid. The azobenzene-containing β-annulus (β-Annulus-Azo) peptide showed a reversible trans/cis isomerization property. The β-annulus-azo peptide self-assembled at 25 μM into capsids with the diameters of 30–50 nm before UV irradiation (trans-form rich), whereas micrometer-sized aggregates were formed after UV irradiation (cis-form rich). The artificial viral capsid possessing azobenzene facilitated the encapsulation of fluorescent-labeled dextrans and their photoinduced release from the capsid. View Full-Text
Keywords: self-assembly; β-annulus peptide; azobenzene; photoisomerization; capsid; guest-molecule release self-assembly; β-annulus peptide; azobenzene; photoisomerization; capsid; guest-molecule release
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MDPI and ACS Style

Matsuura, K.; Fujita, S. A Photoresponsive Artificial Viral Capsid Self-Assembled from an Azobenzene-Containing β-Annulus Peptide. Int. J. Mol. Sci. 2021, 22, 4028. https://doi.org/10.3390/ijms22084028

AMA Style

Matsuura K, Fujita S. A Photoresponsive Artificial Viral Capsid Self-Assembled from an Azobenzene-Containing β-Annulus Peptide. International Journal of Molecular Sciences. 2021; 22(8):4028. https://doi.org/10.3390/ijms22084028

Chicago/Turabian Style

Matsuura, Kazunori, and Seiya Fujita. 2021. "A Photoresponsive Artificial Viral Capsid Self-Assembled from an Azobenzene-Containing β-Annulus Peptide" International Journal of Molecular Sciences 22, no. 8: 4028. https://doi.org/10.3390/ijms22084028

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