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Correction of Heritable Epigenetic Defects Using Editing Tools

by 1,2 and 1,2,*
1
Stem Cell Research Laboratory, Medical Genetics Institute Shaare Zedek Medical Center, Jerusalem 91031, Israel
2
School of Medicine, The Hebrew University, Campus Ein Kerem, Jerusalem 91120, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Agustin F. Fernandez
Int. J. Mol. Sci. 2021, 22(8), 3966; https://doi.org/10.3390/ijms22083966
Received: 9 March 2021 / Revised: 2 April 2021 / Accepted: 7 April 2021 / Published: 12 April 2021
(This article belongs to the Special Issue Molecular Research in Medical Genetics)
Epimutations refer to mistakes in the setting or maintenance of epigenetic marks in the chromatin. They lead to mis-expression of genes and are often secondary to germline transmitted mutations. As such, they are the cause for a considerable number of genetically inherited conditions in humans. The correction of these types of epigenetic defects constitutes a good paradigm to probe the fundamental mechanisms underlying the development of these diseases, and the molecular basis for the establishment, maintenance and regulation of epigenetic modifications in general. Here, we review the data to date, which is limited to repetitive elements, that relates to the applications of key editing tools for addressing the epigenetic aspects of various epigenetically regulated diseases. For each approach we summarize the efforts conducted to date, highlight their contribution to a better understanding of the molecular basis of epigenetic mechanisms, describe the limitations of each approach and suggest perspectives for further exploration in this field. View Full-Text
Keywords: secondary epimutations; repeat associated diseases; genetic editing; epigenetic editing; transcriptional editing; DNA methylation; histone modifications secondary epimutations; repeat associated diseases; genetic editing; epigenetic editing; transcriptional editing; DNA methylation; histone modifications
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MDPI and ACS Style

Handal, T.; Eiges, R. Correction of Heritable Epigenetic Defects Using Editing Tools. Int. J. Mol. Sci. 2021, 22, 3966. https://doi.org/10.3390/ijms22083966

AMA Style

Handal T, Eiges R. Correction of Heritable Epigenetic Defects Using Editing Tools. International Journal of Molecular Sciences. 2021; 22(8):3966. https://doi.org/10.3390/ijms22083966

Chicago/Turabian Style

Handal, Tayma; Eiges, Rachel. 2021. "Correction of Heritable Epigenetic Defects Using Editing Tools" Int. J. Mol. Sci. 22, no. 8: 3966. https://doi.org/10.3390/ijms22083966

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