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Volume 22
Issue 7
10.3390/ijms22073521
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Article

Tau Is Truncated in Five Regions of the Normal Adult Human Brain

by
Michael G. Friedrich
1,2,3,
Amanda Skora
1,
Sarah E. Hancock
4,
Todd W. Mitchell
1,2,3,
Paul L. Else
2 and
Roger J. W. Truscott
1,3,*
1
Illawarra Health and Medical Research Institute, Wollongong University, Wollongong, NSW 2522, Australia
2
School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia
3
Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia
4
School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Michele Sallese
Int. J. Mol. Sci. 2021, 22(7), 3521; https://doi.org/10.3390/ijms22073521
Received: 10 November 2020 / Revised: 24 March 2021 / Accepted: 25 March 2021 / Published: 29 March 2021
(This article belongs to the Special Issue Physiological and Pathological Aspects of Unfolded Protein Response)
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Abstract

The truncation of Tau is thought to be important in promoting aggregation, with this feature characterising the pathology of dementias such as Alzheimer disease. Antibodies to the C-terminal and N-terminal regions of Tau were employed to examine Tau cleavage in five human brain regions: the entorhinal cortex, prefrontal cortex, motor cortex, hippocampus, and cerebellum. These were obtained from normal subjects ranging in age from 18 to 104 years. Tau fragments of approximately 40 kDa and 45 kDa with an intact N-terminus retained were found in soluble and insoluble brain fractions. In addition, smaller C-terminal Tau fragments ranging in mass from 17 kDa to 25 kDa were also detected. These findings are consistent with significant Tau cleavage taking place in brain regions from 18 years onwards. It appears that site-specific cleavage of Tau is widespread in the normal human brain, and that large Tau fragments that contain the N-terminus, as well as shorter C-terminal Tau fragments, are present in brain cells across the age range. View Full-Text
Keywords: Tau; ageing; Alzheimer disease; truncation; protein unfolding; protein truncation Tau; ageing; Alzheimer disease; truncation; protein unfolding; protein truncation
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MDPI and ACS Style

Friedrich, M.G.; Skora, A.; Hancock, S.E.; Mitchell, T.W.; Else, P.L.; Truscott, R.J.W. Tau Is Truncated in Five Regions of the Normal Adult Human Brain. Int. J. Mol. Sci. 2021, 22, 3521. https://doi.org/10.3390/ijms22073521

AMA Style

Friedrich MG, Skora A, Hancock SE, Mitchell TW, Else PL, Truscott RJW. Tau Is Truncated in Five Regions of the Normal Adult Human Brain. International Journal of Molecular Sciences. 2021; 22(7):3521. https://doi.org/10.3390/ijms22073521

Chicago/Turabian Style

Friedrich, Michael G., Amanda Skora, Sarah E. Hancock, Todd W. Mitchell, Paul L. Else, and Roger J.W. Truscott. 2021. "Tau Is Truncated in Five Regions of the Normal Adult Human Brain" International Journal of Molecular Sciences 22, no. 7: 3521. https://doi.org/10.3390/ijms22073521

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