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Volume 22
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10.3390/ijms22063257
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Article

Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition

by
Quentin de Roux
1,2,3,
Fanny Lidouren
2,3,
Agathe Kudela
1,2,3,
Lina Slassi
2,3,
Matthias Kohlhauer
2,3,
Emilie Boissady
2,3,
Matthieu Chalopin
4,
Géraldine Farjot
4,
Catherine Billoet
4,
Patrick Bruneval
5,
Bijan Ghaleh
2,3,
Nicolas Mongardon
1,2,3 and
Renaud Tissier
2,3,*
1
Service D’anesthésie–Réanimation Chirurgicale, DMU CARE, DHU A–TVB, Hôpitaux Universitaires Henri Mondor, Assistance Publique–Hôpitaux de Paris (AP–HP), F-94010 Créteil, France
2
The Mondor Institute for Biomedical Research, Institut National de la Santé et de la Recherche Médicale, University Paris Est Créteil, F-94010 Créteil, France
3
The Mondor Institute for Biomedical Research, Ecole Nationale Vétérinaire d’Alfort, F-94700 Maisons-Alfort, France
4
Air Liquide Santé International, Centre Innovation Paris, F-78350 Les Loges en Josas, France
5
UMR 970, Paris Cardiovascular Research Center, INSERM, Hôpital Européen Georges Pompidou, F-75015 Paris, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(6), 3257; https://doi.org/10.3390/ijms22063257
Submission received: 9 March 2021 / Revised: 17 March 2021 / Accepted: 19 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Cardiovascular Pharmacology and Interventions: Future Directions for Cardioprotection)
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Abstract

Argon inhalation attenuates multiorgan failure (MOF) after experimental ischemic injury. We hypothesized that this protection could involve decreased High Mobility Group Box 1 (HMGB1) systemic release. We investigated this issue in an animal model of MOF induced by aortic cross-clamping. Anesthetized rabbits were submitted to supra-coeliac aortic cross-clamping for 30 min, followed by 300 min of reperfusion. They were randomly divided into three groups (n = 7/group). The Control group inhaled nitrogen (70%) and oxygen (30%). The Argon group was exposed to a mixture of argon (70%) and oxygen (30%). The last group inhaled nitrogen/oxygen (70/30%) with an administration of the HMGB1 inhibitor glycyrrhizin (4 mg/kg i.v.) 5 min before aortic unclamping. At the end of follow-up, cardiac output was significantly higher in Argon and Glycyrrhizin vs. Control (60 ± 4 and 49 ± 4 vs. 33 ± 8 mL/kg/min, respectively). Metabolic acidosis was attenuated in Argon and Glycyrrhizin vs. Control, along with reduced amount of norepinephrine to reverse arterial hypotension. This was associated with reduced interleukin-6 and HMGB1 plasma concentration in Argon and Glycyrrhizin vs. Control. End-organ damages were also attenuated in the liver and kidney in Argon and Glycyrrhizin vs. Control, respectively. Argon inhalation reduced HMGB1 blood level after experimental aortic cross-clamping and provided similar benefits to direct HMGB1 inhibition.
Keywords: argon; multiorgan failure; ischemia-reperfusion; inflammation; High Mobility Group Box 1 (HMGB1) argon; multiorgan failure; ischemia-reperfusion; inflammation; High Mobility Group Box 1 (HMGB1)

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MDPI and ACS Style

de Roux, Q.; Lidouren, F.; Kudela, A.; Slassi, L.; Kohlhauer, M.; Boissady, E.; Chalopin, M.; Farjot, G.; Billoet, C.; Bruneval, P.; et al. Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition. Int. J. Mol. Sci. 2021, 22, 3257. https://doi.org/10.3390/ijms22063257

AMA Style

de Roux Q, Lidouren F, Kudela A, Slassi L, Kohlhauer M, Boissady E, Chalopin M, Farjot G, Billoet C, Bruneval P, et al. Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition. International Journal of Molecular Sciences. 2021; 22(6):3257. https://doi.org/10.3390/ijms22063257

Chicago/Turabian Style

de Roux, Quentin, Fanny Lidouren, Agathe Kudela, Lina Slassi, Matthias Kohlhauer, Emilie Boissady, Matthieu Chalopin, Géraldine Farjot, Catherine Billoet, Patrick Bruneval, and et al. 2021. "Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition" International Journal of Molecular Sciences 22, no. 6: 3257. https://doi.org/10.3390/ijms22063257

APA Style

de Roux, Q., Lidouren, F., Kudela, A., Slassi, L., Kohlhauer, M., Boissady, E., Chalopin, M., Farjot, G., Billoet, C., Bruneval, P., Ghaleh, B., Mongardon, N., & Tissier, R. (2021). Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition. International Journal of Molecular Sciences, 22(6), 3257. https://doi.org/10.3390/ijms22063257

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