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Article

Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters

1
National Institute of Mental Health, Topolova 748, 25067 Klecany, Czech Republic
2
Laboratory of the Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic
3
First Faculty of Medicine, Charles University, Katerinska 32, 12108 Prague 2, Czech Republic
4
Faculty of Science, Charles University, Albertov 6, 12800 Prague 2, Czech Republic
*
Authors to whom correspondence should be addressed.
Academic Editor: Ali Gorji
Int. J. Mol. Sci. 2021, 22(6), 3274; https://doi.org/10.3390/ijms22063274
Received: 25 February 2021 / Revised: 18 March 2021 / Accepted: 20 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Neuroinflammation: The Pathogenic Mechanism of Neurological Disorders)
Maternal immune activation (MIA) during pregnancy represents an important environmental factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to investigate the impacts of MIA on the brain and behavior of adolescent and adult offspring, as a rat model of these neurodevelopmental disorders. We injected bacterial lipopolysaccharide (LPS, 1 mg/kg) to pregnant Wistar dams from gestational day 7, every other day, up to delivery. Behavior of the offspring was examined in a comprehensive battery of tasks at postnatal days P45 and P90. Several brain parameters were analyzed at P28. The results showed that prenatal immune activation caused social and communication impairments in the adult offspring of both sexes; males were affected already in adolescence. MIA also caused prepulse inhibition deficit in females and increased the startle reaction in males. Anxiety and hypolocomotion were apparent in LPS-affected males and females. In the 28-day-old LPS offspring, we found enlargement of the brain and decreased numbers of parvalbumin-positive interneurons in the frontal cortex in both sexes. To conclude, our data indicate that sex of the offspring plays a crucial role in the development of the MIA-induced behavioral alterations, whereas changes in the brain apparent in young animals are sex-independent. View Full-Text
Keywords: lipopolysaccharide; maternal immune activation; prenatal infection; chronic bacterial infection; parvalbumin-positive interneurons; macrocephaly; schizophrenia; autism; sex differences; development lipopolysaccharide; maternal immune activation; prenatal infection; chronic bacterial infection; parvalbumin-positive interneurons; macrocephaly; schizophrenia; autism; sex differences; development
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MDPI and ACS Style

Vojtechova, I.; Maleninska, K.; Kutna, V.; Klovrza, O.; Tuckova, K.; Petrasek, T.; Stuchlik, A. Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters. Int. J. Mol. Sci. 2021, 22, 3274. https://doi.org/10.3390/ijms22063274

AMA Style

Vojtechova I, Maleninska K, Kutna V, Klovrza O, Tuckova K, Petrasek T, Stuchlik A. Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters. International Journal of Molecular Sciences. 2021; 22(6):3274. https://doi.org/10.3390/ijms22063274

Chicago/Turabian Style

Vojtechova, Iveta, Kristyna Maleninska, Viera Kutna, Ondrej Klovrza, Klara Tuckova, Tomas Petrasek, and Ales Stuchlik. 2021. "Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters" International Journal of Molecular Sciences 22, no. 6: 3274. https://doi.org/10.3390/ijms22063274

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