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Volume 22
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10.3390/ijms22063047
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Open AccessArticle

β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (Acomys cahirinus) Model

by
Ewa Tomaszewska
1,*,
Janine Donaldson
2,
Jakub Kosiński
3,
Piotr Dobrowolski
4,
Agnieszka Tomczyk-Warunek
3,
Monika Hułas-Stasiak
4,
Krzysztof Lamorski
5,
Dorota Laskowska-Woźniak
6,
Siemowit Muszyński
6,
Rudolf Blicharski
3 and
Tomasz Blicharski
3
1
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka St. 12, 20-950 Lublin, Poland
2
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
3
Department of Rehabilitation and Orthopaedics, Medical University in Lublin, Jaczewskiego St. 8, 20-090 Lublin, Poland
4
Department of Functional Anatomy and Cytobiology, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka St. 19, 20-033 Lublin, Poland
5
Bohdan Dobrzański Institute of Agrophysics of the Polish Academy of Sciences, Doświadczalna St. 4, 20-290 Lublin, Poland
6
Department of Biophysics, Faculty of Environmental Biology, University of Life Sciences in Lublin, Akademicka St. 13, 20-950 Lublin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Elizabeth W. Bradley
Int. J. Mol. Sci. 2021, 22(6), 3047; https://doi.org/10.3390/ijms22063047
Received: 9 February 2021 / Revised: 15 March 2021 / Accepted: 15 March 2021 / Published: 17 March 2021
(This article belongs to the Special Issue Musculoskeletal Development and Skeletal Pathophysiologies)
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Abstract

The aim of this study was to determine the effects of ß-hydroxy-ß-methylbutyrate (HMB) supplementation during pregnancy on postpartum bone tissue quality by assessing changes in trabecular and compact bone as well as in hyaline and epiphyseal cartilage. The experiment was carried out on adult 6-month-old female spiny mice (Acomys cahirinus) divided into three groups: pregnant control (PregCont), pregnant HMB-treated (supplemented with 0.02 g/kg b.w of HMB during the second trimester of pregnancy, PregHMB), and non-pregnant females (NonPreg). Cross-sectional area and cortical index of the femoral mid-shaft, stiffness, and Young modulus were significantly greater in the PregHMB group. Whole-bone mineral density was similar in all groups, and HMB supplementation increased trabecular number. Growth plate cartilage was the thinnest, while the articular cartilage was the thickest in the PregHMB group. HMB supplementation increased the content of proteoglycans in the articular cartilage and the percentage of immature collagen content in metaphyseal trabeculae and compact bone. In summary, dietary HMB supplementation during the second trimester of pregnancy intensifies bone metabolic processes and prevents bone loss during pregnancy. View Full-Text
Keywords: β-hydroxy-β-methylbutyrate; pregnancy; bone; spiny mouse model β-hydroxy-β-methylbutyrate; pregnancy; bone; spiny mouse model
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MDPI and ACS Style

Tomaszewska, E.; Donaldson, J.; Kosiński, J.; Dobrowolski, P.; Tomczyk-Warunek, A.; Hułas-Stasiak, M.; Lamorski, K.; Laskowska-Woźniak, D.; Muszyński, S.; Blicharski, R.; Blicharski, T. β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (Acomys cahirinus) Model. Int. J. Mol. Sci. 2021, 22, 3047. https://doi.org/10.3390/ijms22063047

AMA Style

Tomaszewska E, Donaldson J, Kosiński J, Dobrowolski P, Tomczyk-Warunek A, Hułas-Stasiak M, Lamorski K, Laskowska-Woźniak D, Muszyński S, Blicharski R, Blicharski T. β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (Acomys cahirinus) Model. International Journal of Molecular Sciences. 2021; 22(6):3047. https://doi.org/10.3390/ijms22063047

Chicago/Turabian Style

Tomaszewska, Ewa; Donaldson, Janine; Kosiński, Jakub; Dobrowolski, Piotr; Tomczyk-Warunek, Agnieszka; Hułas-Stasiak, Monika; Lamorski, Krzysztof; Laskowska-Woźniak, Dorota; Muszyński, Siemowit; Blicharski, Rudolf; Blicharski, Tomasz. 2021. "β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (Acomys cahirinus) Model" Int. J. Mol. Sci. 22, no. 6: 3047. https://doi.org/10.3390/ijms22063047

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