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Commentary

Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis

Center for Stem Cells and Regenerative Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Masato Sato
Int. J. Mol. Sci. 2021, 22(6), 2838; https://doi.org/10.3390/ijms22062838
Received: 28 January 2021 / Revised: 1 March 2021 / Accepted: 1 March 2021 / Published: 11 March 2021
We have been studying mesenchymal stem cells (MSCs) in synovial fluid and the intra-articular injection of synovial MSCs in osteoarthritis (OA) knees. Here, mainly based on our own findings, we overview the characteristics of endogenous MSCs in the synovial fluid of OA knees and their mode of action when injected exogenously into OA knees. Many MSCs similar to synovial MSCs were detected in the synovial fluid of human OA knees, and their number correlated with the radiological OA grade. Our suspended synovium culture model demonstrated the release of MSCs from the synovium through a medium into a non-contacting culture dish. In OA knees, endogenous MSCs possibly mobilize in a similar manner from the synovium through the synovial fluid and act protectively. However, the number of mobilized MSCs is limited; therefore, OA progresses in its natural course. Synovial MSC injections inhibited the progression of cartilage degeneration in a rat OA model. Injected synovial MSCs migrated into the synovium, maintained their MSC properties, and increased the gene expressions of TSG-6, PRG-4, and BMP-2. Exogenous synovial MSCs can promote anti-inflammation, lubrication, and cartilage matrix synthesis in OA knees. Based on our findings, we have initiated a human clinical study of synovial MSC injections in OA knees. View Full-Text
Keywords: MSC; synovial fluid; mode of action; injection; synovium; knee; osteoarthritis; TSG-6; PRG-4; BMP-2 MSC; synovial fluid; mode of action; injection; synovium; knee; osteoarthritis; TSG-6; PRG-4; BMP-2
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MDPI and ACS Style

Sekiya, I.; Katano, H.; Ozeki, N. Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis. Int. J. Mol. Sci. 2021, 22, 2838. https://doi.org/10.3390/ijms22062838

AMA Style

Sekiya I, Katano H, Ozeki N. Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis. International Journal of Molecular Sciences. 2021; 22(6):2838. https://doi.org/10.3390/ijms22062838

Chicago/Turabian Style

Sekiya, Ichiro; Katano, Hisako; Ozeki, Nobutake. 2021. "Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis" Int. J. Mol. Sci. 22, no. 6: 2838. https://doi.org/10.3390/ijms22062838

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