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Open AccessReview

Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer

1
Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
2
Center of Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
3
Department of Gastroenterology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Michel Sève
Int. J. Mol. Sci. 2021, 22(5), 2655; https://doi.org/10.3390/ijms22052655
Received: 27 January 2021 / Revised: 26 February 2021 / Accepted: 2 March 2021 / Published: 6 March 2021
(This article belongs to the Special Issue Recent Advances of Proteomics Applied to Cancer and Human Diseases)
Pancreatic ductal adenocarcinoma (PDAC) is known as a highly aggressive malignant disease. Prognosis for patients is notoriously poor, despite improvements in surgical techniques and new (neo)adjuvant chemotherapy regimens. Early detection of PDAC may increase the overall survival. It is furthermore foreseen that precision medicine will provide improved prognostic stratification and prediction of therapeutic response. In this review, omics-based discovery efforts are presented that aim for novel diagnostic and prognostic biomarkers of PDAC. For this purpose, we systematically evaluated the literature published between 1999 and 2020 with a focus on protein- and protein-glycosylation biomarkers in pancreatic cancer patients. Besides genomic and transcriptomic approaches, mass spectrometry (MS)-based proteomics and glycomics of blood- and tissue-derived samples from PDAC patients have yielded new candidates with biomarker potential. However, for reasons discussed in this review, the validation and clinical translation of these candidate markers has not been successful. Consequently, there has been a change of mindset from initial efforts to identify new unimarkers into the current hypothesis that a combination of biomarkers better suits a diagnostic or prognostic panel. With continuing development of current research methods and available techniques combined with careful study designs, new biomarkers could contribute to improved detection, prognosis, and prediction of pancreatic cancer. View Full-Text
Keywords: pancreatic cancer; biomarker; mass spectrometry; proteomics; glycomics; glycosylation; early detection; prediction; prognosis; CA 19-9 pancreatic cancer; biomarker; mass spectrometry; proteomics; glycomics; glycosylation; early detection; prediction; prognosis; CA 19-9
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MDPI and ACS Style

Hanna-Sawires, R.G.; Schiphuis, J.H.; Wuhrer, M.; Vasen, H.F.A.; van Leerdam, M.E.; Bonsing, B.A.; Mesker, W.E.; van der Burgt, Y.E.M.; Tollenaar, R.A.E.M. Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer. Int. J. Mol. Sci. 2021, 22, 2655. https://doi.org/10.3390/ijms22052655

AMA Style

Hanna-Sawires RG, Schiphuis JH, Wuhrer M, Vasen HFA, van Leerdam ME, Bonsing BA, Mesker WE, van der Burgt YEM, Tollenaar RAEM. Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer. International Journal of Molecular Sciences. 2021; 22(5):2655. https://doi.org/10.3390/ijms22052655

Chicago/Turabian Style

Hanna-Sawires, Randa G.; Schiphuis, Jorinde H.; Wuhrer, Manfred; Vasen, Hans F.A.; van Leerdam, Monique E.; Bonsing, Bert A.; Mesker, Wilma E.; van der Burgt, Yuri E.M.; Tollenaar, Rob A.E.M. 2021. "Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer" Int. J. Mol. Sci. 22, no. 5: 2655. https://doi.org/10.3390/ijms22052655

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