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The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration

1
Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684, USA
2
Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland
3
Center for Molecular Medicine and Stem Cell Research, Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia
*
Author to whom correspondence should be addressed.
Academic Editor: Kathy Lui
Int. J. Mol. Sci. 2021, 22(5), 2472; https://doi.org/10.3390/ijms22052472
Received: 31 January 2021 / Revised: 16 February 2021 / Accepted: 17 February 2021 / Published: 1 March 2021
(This article belongs to the Special Issue Immune Cell Mediated Tissue Regeneration)
Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration. View Full-Text
Keywords: mesenchymal stem cells; immune cells; immunomodulation; angiogenesis; regeneration mesenchymal stem cells; immune cells; immunomodulation; angiogenesis; regeneration
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MDPI and ACS Style

Harrell, C.R.; Djonov, V.; Volarevic, V. The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration. Int. J. Mol. Sci. 2021, 22, 2472. https://doi.org/10.3390/ijms22052472

AMA Style

Harrell CR, Djonov V, Volarevic V. The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration. International Journal of Molecular Sciences. 2021; 22(5):2472. https://doi.org/10.3390/ijms22052472

Chicago/Turabian Style

Harrell, Carl R.; Djonov, Valentin; Volarevic, Vladislav. 2021. "The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration" Int. J. Mol. Sci. 22, no. 5: 2472. https://doi.org/10.3390/ijms22052472

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