Next Article in Journal
Comparative Genomics: Insights on the Pathogenicity and Lifestyle of Rhizoctonia solani
Next Article in Special Issue
The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
Previous Article in Journal
Altered Expression of OsAAP3 Influences Rice Lesion Mimic and Leaf Senescence by Regulating Arginine Transport and Nitric Oxide Pathway
Previous Article in Special Issue
Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold
Open AccessArticle

Increased Expression of Ephrins on Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis Affects Oligodendrocyte Differentiation

1
The Neuroimmunology and Multiple Sclerosis Unit, Neurology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
2
Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
3
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Kathy Lui
Int. J. Mol. Sci. 2021, 22(4), 2182; https://doi.org/10.3390/ijms22042182
Received: 28 January 2021 / Revised: 17 February 2021 / Accepted: 19 February 2021 / Published: 22 February 2021
(This article belongs to the Special Issue Immune Cell Mediated Tissue Regeneration)
The effect of the inflammatory response on regenerative processes in the brain is complex. This complexity is even greater when the cause of the tissue damage is an autoimmune response. Multiple sclerosis (MS) is an immune-mediated disease in which demyelination foci are formed in the central nervous system. The degree of repair through oligodendrocyte regeneration and remyelination is insufficient. Ephrins are membrane-bound ligands activating tyrosine kinase signaling proteins that are known to have an inhibitory effect on oligodendrocyte regeneration. In this study, we examined the expression of ephrins on immune cells of 43 patients with relapsing-remitting (RR) MS compared to 27 matched healthy controls (HC). We found an increased expression of ephrin-A2, -A3 and -B3, especially on T cell subpopulations. We also showed overexpression of ephrins on immune cells of patients with RR-MS that increases the forward signaling pathway and that expression of ephrins on immune cells has an inhibitory effect on the differentiation of oligodendrocyte precursor cells (OPCs) in vitro. Our study findings support the concept that the immune activity of T cells in patients with RR-MS has an inhibitory effect on the differentiation capacity of OPCs through the expression and forward signaling of ephrins. View Full-Text
Keywords: multiple sclerosis; T cells; ephrins; oligodendrocyte precursor cells; oligodendrocyte differentiation multiple sclerosis; T cells; ephrins; oligodendrocyte precursor cells; oligodendrocyte differentiation
Show Figures

Graphical abstract

MDPI and ACS Style

Golan, M.; Krivitsky, A.; Mausner-Fainberg, K.; Benhamou, M.; Vigiser, I.; Regev, K.; Kolb, H.; Karni, A. Increased Expression of Ephrins on Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis Affects Oligodendrocyte Differentiation. Int. J. Mol. Sci. 2021, 22, 2182. https://doi.org/10.3390/ijms22042182

AMA Style

Golan M, Krivitsky A, Mausner-Fainberg K, Benhamou M, Vigiser I, Regev K, Kolb H, Karni A. Increased Expression of Ephrins on Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis Affects Oligodendrocyte Differentiation. International Journal of Molecular Sciences. 2021; 22(4):2182. https://doi.org/10.3390/ijms22042182

Chicago/Turabian Style

Golan, Maya; Krivitsky, Avivit; Mausner-Fainberg, Karin; Benhamou, Moshe; Vigiser, Ifat; Regev, Keren; Kolb, Hadar; Karni, Arnon. 2021. "Increased Expression of Ephrins on Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis Affects Oligodendrocyte Differentiation" Int. J. Mol. Sci. 22, no. 4: 2182. https://doi.org/10.3390/ijms22042182

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop