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Review

Molecular Regulation of Canalicular ABC Transporters

by
Amel Ben Saad
1,2,†,
Alix Bruneau
2,3,†,
Elodie Mareux
1,†,
Martine Lapalus
1,
Jean-Louis Delaunay
2,
Emmanuel Gonzales
1,4,
Emmanuel Jacquemin
1,4,
Tounsia Aït-Slimane
2,‡ and
Thomas Falguières
1,*,‡
1
Physiopathogénèse et Traitement des Maladies du foie, Inserm, Université Paris-Saclay, UMR_S 1193, Hepatinov, 91400 Orsay, France
2
Centre de Recherche Saint-Antoine (CRSA), Inserm, Sorbonne Université, UMR_S 938, Institute of Cardiometabolism and Nutrition (ICAN), 75012 Paris, France
3
Department of Hepatology and Gastroenterology, Charité Universitäts Medizin Berlin, 13353 Berlin, Germany
4
Paediatric Hepatology and Paediatric Liver Transplant Department, Reference Center for Rare Paediatric Liver Diseases, FILFOIE, ERN RARE LIVER, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Paris-Saclay, CHU Bicêtre, 94270 Le Kremlin-Bicêtre, France
*
Author to whom correspondence should be addressed.
†
These authors share first co-authorship.
‡
These authors share last co-authorship.
Int. J. Mol. Sci. 2021, 22(4), 2113; https://doi.org/10.3390/ijms22042113
Submission received: 1 February 2021 / Revised: 15 February 2021 / Accepted: 18 February 2021 / Published: 20 February 2021
(This article belongs to the Special Issue ABC Transporters in Human Diseases)
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Abstract

The ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of hepatocytes mediate the secretion of several compounds into the bile canaliculi and therefore play a key role in bile secretion. Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds. The dysfunction of these transporters leads to severe, rare, evolutionary biliary diseases. The development of new therapies for patients with these diseases requires a deep understanding of the biology of these transporters. In this review, we report the current knowledge regarding the regulation of canalicular ABC transporters’ folding, trafficking, membrane stability and function, and we highlight the role of molecular partners in these regulating mechanisms.
Keywords: bile secretion; ABCB1; ABCB4; ABCB11; ABCC2; ABCG5/G8; molecular partners bile secretion; ABCB1; ABCB4; ABCB11; ABCC2; ABCG5/G8; molecular partners

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MDPI and ACS Style

Ben Saad, A.; Bruneau, A.; Mareux, E.; Lapalus, M.; Delaunay, J.-L.; Gonzales, E.; Jacquemin, E.; Aït-Slimane, T.; Falguières, T. Molecular Regulation of Canalicular ABC Transporters. Int. J. Mol. Sci. 2021, 22, 2113. https://doi.org/10.3390/ijms22042113

AMA Style

Ben Saad A, Bruneau A, Mareux E, Lapalus M, Delaunay J-L, Gonzales E, Jacquemin E, Aït-Slimane T, Falguières T. Molecular Regulation of Canalicular ABC Transporters. International Journal of Molecular Sciences. 2021; 22(4):2113. https://doi.org/10.3390/ijms22042113

Chicago/Turabian Style

Ben Saad, Amel, Alix Bruneau, Elodie Mareux, Martine Lapalus, Jean-Louis Delaunay, Emmanuel Gonzales, Emmanuel Jacquemin, Tounsia Aït-Slimane, and Thomas Falguières. 2021. "Molecular Regulation of Canalicular ABC Transporters" International Journal of Molecular Sciences 22, no. 4: 2113. https://doi.org/10.3390/ijms22042113

APA Style

Ben Saad, A., Bruneau, A., Mareux, E., Lapalus, M., Delaunay, J.-L., Gonzales, E., Jacquemin, E., Aït-Slimane, T., & Falguières, T. (2021). Molecular Regulation of Canalicular ABC Transporters. International Journal of Molecular Sciences, 22(4), 2113. https://doi.org/10.3390/ijms22042113

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