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Volume 22
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10.3390/ijms22042002
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Review

Outcomes of Lower Extremity Endovascular Revascularization: Potential Predictors and Prevention Strategies

by
Federico Biscetti
1,2,*,†,
Elisabetta Nardella
3,†,
Maria Margherita Rando
1,2,
Andrea Leonardo Cecchini
3,
Antonio Gasbarrini
1,3,
Massimo Massetti
1,4 and
Andrea Flex
1,2,3
1
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
2
Cardiovascular Internal Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
3
Department of Medical and Surgical Sciences, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
4
Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2021, 22(4), 2002; https://doi.org/10.3390/ijms22042002
Submission received: 29 December 2020 / Revised: 11 February 2021 / Accepted: 12 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue Peripheral Artery Disease: From Molecular Mechanisms to Therapeutic Approaches)
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Abstract

Peripheral artery disease (PAD) is a manifestation of atherosclerosis, which may affect arteries of the lower extremities. The most dangerous PAD complication is chronic limb-threatening ischemia (CLTI). Without revascularization, CLTI often causes limb loss. However, neither open surgical revascularization nor endovascular treatment (EVT) ensure long-term success and freedom from restenosis and revascularization failure. In recent years, EVT has gained growing acceptance among all vascular specialties, becoming the primary approach of revascularization in patients with CLTI. In clinical practice, different clinical outcomes after EVT in patients with similar comorbidities undergoing the same procedure (in terms of revascularization technique and localization of the disease) cause unsolved issues that need to be addressed. Nowadays, risk management of revascularization failure is one of the major challenges in the vascular field. The aim of this literature review is to identify potential predictors for lower extremity endovascular revascularization outcomes and possible prevention strategies.
Keywords: peripheral artery disease (PAD); chronic limb-threatening ischemia (CLTI); revascularization peripheral artery disease (PAD); chronic limb-threatening ischemia (CLTI); revascularization

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MDPI and ACS Style

Biscetti, F.; Nardella, E.; Rando, M.M.; Cecchini, A.L.; Gasbarrini, A.; Massetti, M.; Flex, A. Outcomes of Lower Extremity Endovascular Revascularization: Potential Predictors and Prevention Strategies. Int. J. Mol. Sci. 2021, 22, 2002. https://doi.org/10.3390/ijms22042002

AMA Style

Biscetti F, Nardella E, Rando MM, Cecchini AL, Gasbarrini A, Massetti M, Flex A. Outcomes of Lower Extremity Endovascular Revascularization: Potential Predictors and Prevention Strategies. International Journal of Molecular Sciences. 2021; 22(4):2002. https://doi.org/10.3390/ijms22042002

Chicago/Turabian Style

Biscetti, Federico, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Antonio Gasbarrini, Massimo Massetti, and Andrea Flex. 2021. "Outcomes of Lower Extremity Endovascular Revascularization: Potential Predictors and Prevention Strategies" International Journal of Molecular Sciences 22, no. 4: 2002. https://doi.org/10.3390/ijms22042002

APA Style

Biscetti, F., Nardella, E., Rando, M. M., Cecchini, A. L., Gasbarrini, A., Massetti, M., & Flex, A. (2021). Outcomes of Lower Extremity Endovascular Revascularization: Potential Predictors and Prevention Strategies. International Journal of Molecular Sciences, 22(4), 2002. https://doi.org/10.3390/ijms22042002

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