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Article

Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation

by
Maurizio Mennini
1,†,
Sofia Reddel
2,†,
Federica Del Chierico
2,
Simone Gardini
3,
Andrea Quagliariello
2,
Pamela Vernocchi
2,
Rocco Luigi Valluzzi
1,
Vincenzo Fierro
1,
Carla Riccardi
1,
Tania Napolitano
1,
Alessandro Giovanni Fiocchi
1,‡ and
Lorenza Putignani
4,*,‡
1
Translational Research in Pediatric Specialities Area, Allergy Unit, Bambino Gesù Children’s Hospital, IRCCS, 00147 Rome, Italy
2
Multimodal Laboratory Medicine Research Area, Unit of Human Microbiome, Bambino Gesù Children’s Hospital, IRCCS, 00147 Rome, Italy
3
GenomeUp, Via Nemorense 91, 00199 Rome, Italy
4
Department of Diagnostic and Laboratory Medicine, Unit of Parasitology and Multimodal Laboratory Medicine Research Area, Unit of Human Microbiome, Bambino Gesù Children’s Hospital, IRCCS, 00147 Rome, Italy
*
Author to whom correspondence should be addressed.
†
Co-first authorship.
‡
Co-last authorship.
Int. J. Mol. Sci. 2021, 22(4), 1649; https://doi.org/10.3390/ijms22041649
Submission received: 11 January 2021 / Revised: 2 February 2021 / Accepted: 3 February 2021 / Published: 6 February 2021
(This article belongs to the Special Issue Gut Microbioma in Childhood Health and Disease)
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Abstract

Food allergy (FA) and, in particular, IgE-mediated cow’s milk allergy is associated with compositional and functional changes of gut microbiota. In this study, we compared the gut microbiota of cow’s milk allergic (CMA) infants with that of cow’s milk sensitized (CMS) infants and Healthy controls. The effect of the intake of a mixture of Bifidobacterium longum subsp. longum BB536, Bifidobacterium breve M-16V and Bifidobacterium longum subsp. infantis M-63 on gut microbiota modulation of CMA infants and probiotic persistence was also investigated. Gut microbiota of CMA infants resulted to be characterized by a dysbiotic status with a prevalence of some bacteria as Haemophilus, Klebsiella, Prevotella, Actinobacillus and Streptococcus. Among the three strains administered, B.longum subsp. infantis colonized the gastrointestinal tract and persisted in the gut microbiota of infants with CMA for 60 days. This colonization was associated with perturbations of the gut microbiota, specifically with the increase of Akkermansia and Ruminococcus. Multi-strain probiotic formulations can be studied for their persistence in the intestine by monitoring specific bacterial probes persistence and exploiting microbiota profiling modulation before the evaluation of their therapeutic effects.
Keywords: cow’s milk allergic (CMA); cow’s milk sensitized (CMS); probiotics; quantitative real-time PCR assays; gut microbiota profiling cow’s milk allergic (CMA); cow’s milk sensitized (CMS); probiotics; quantitative real-time PCR assays; gut microbiota profiling

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MDPI and ACS Style

Mennini, M.; Reddel, S.; Del Chierico, F.; Gardini, S.; Quagliariello, A.; Vernocchi, P.; Valluzzi, R.L.; Fierro, V.; Riccardi, C.; Napolitano, T.; et al. Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation. Int. J. Mol. Sci. 2021, 22, 1649. https://doi.org/10.3390/ijms22041649

AMA Style

Mennini M, Reddel S, Del Chierico F, Gardini S, Quagliariello A, Vernocchi P, Valluzzi RL, Fierro V, Riccardi C, Napolitano T, et al. Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation. International Journal of Molecular Sciences. 2021; 22(4):1649. https://doi.org/10.3390/ijms22041649

Chicago/Turabian Style

Mennini, Maurizio, Sofia Reddel, Federica Del Chierico, Simone Gardini, Andrea Quagliariello, Pamela Vernocchi, Rocco Luigi Valluzzi, Vincenzo Fierro, Carla Riccardi, Tania Napolitano, and et al. 2021. "Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation" International Journal of Molecular Sciences 22, no. 4: 1649. https://doi.org/10.3390/ijms22041649

APA Style

Mennini, M., Reddel, S., Del Chierico, F., Gardini, S., Quagliariello, A., Vernocchi, P., Valluzzi, R. L., Fierro, V., Riccardi, C., Napolitano, T., Fiocchi, A. G., & Putignani, L. (2021). Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation. International Journal of Molecular Sciences, 22(4), 1649. https://doi.org/10.3390/ijms22041649

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