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Review

Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome

1
Department of Experimental Cardiology, Amsterdam University Medical Center, Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
2
Department of Medical Biology, Amsterdam University Medical Center, Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
3
IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, 33600 Bordeaux, France
4
UMR5251, Institut de Mathématiques de Bordeaux, Université de Bordeaux, 33400 Talence, France
5
Carmen Team, INRIA Bordeaux—Sud-Ouest, 33400 Talence, France
*
Author to whom correspondence should be addressed.
Academic Editors: Carlo Pappone and Michelle Monasky
Int. J. Mol. Sci. 2021, 22(4), 1570; https://doi.org/10.3390/ijms22041570
Received: 15 January 2021 / Revised: 28 January 2021 / Accepted: 29 January 2021 / Published: 4 February 2021
(This article belongs to the Special Issue Brugada Syndrome: Causes, Diagnosis, and Treatment)
Brugada syndrome and early repolarization syndrome are both classified as J-wave syndromes, with a similar mechanism of arrhythmogenesis and with the same basis for genesis of the characteristic electrocardiographic features. The Brugada syndrome is now considered a conduction disorder based on subtle structural abnormalities in the right ventricular outflow tract. Recent evidence suggests structural substrate in patients with the early repolarization syndrome as well. We propose a unifying mechanism based on these structural abnormalities explaining both arrhythmogenesis and the electrocardiographic changes. In addition, we speculate that, with increasing technical advances in imaging techniques and their spatial resolution, these syndromes will be reclassified as structural heart diseases or cardiomyopathies. View Full-Text
Keywords: arrhythmias; Brugada syndrome; early repolarization pattern; fibrosis; conduction; repolarization arrhythmias; Brugada syndrome; early repolarization pattern; fibrosis; conduction; repolarization
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MDPI and ACS Style

Boukens, B.J.; Potse, M.; Coronel, R. Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome. Int. J. Mol. Sci. 2021, 22, 1570. https://doi.org/10.3390/ijms22041570

AMA Style

Boukens BJ, Potse M, Coronel R. Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome. International Journal of Molecular Sciences. 2021; 22(4):1570. https://doi.org/10.3390/ijms22041570

Chicago/Turabian Style

Boukens, Bastiaan J., Mark Potse, and Ruben Coronel. 2021. "Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome" International Journal of Molecular Sciences 22, no. 4: 1570. https://doi.org/10.3390/ijms22041570

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